Pagliarini S, Moramarco A, Wormald R P, Piguet B, Carresi C, Balacco-Gabrieli C, Sehmi K S, Bird A C
Queen's Medical Center, University Hospital Nottingham, England.
Arch Ophthalmol. 1997 May;115(5):616-22. doi: 10.1001/archopht.1997.01100150618007.
To report the prevalence of age-related maculopathy (ARM) in Salandra, a small, isolated southern Italian community, to test the hypothesis that an environmental factor, scarce in such a remote community but ubiquitous in modern industrial societies, might modify the risk of developing ARM.
Population-based cross-sectional survey.
Prevalence of advanced age-related macular degeneration (ARMD) (geographic atrophy or exudative maculopathy) and ARM (large, soft drusen or retinal pigment epithelium changes, or both) defined by fundus biomicroscopy and 30 degrees stereoscopic, macular photography. Self-sustenance was assessed by interview of participants and local shop retailers. The degree of genetic isolation was computed using a model that fits the genetic population structure with the frequency distribution of surnames in the community.
A full ophthalmic examination was undertaken in 366 (63.5%) of 576 eligible participants, 354 (96.7%) of whom had clinical or photographic assessment for the presence of ARMD and 310 (84.6%) of whom had drusen characteristics graded on color transparencies for ARM. The overall prevalence of ARMD was 1.1%. Drusen larger than 50 microns and more numerous than 10 were found in 4.5% of subjects. Salandra was the birthplace of 87.2% of participants and for 77.3% of both parents of each subject. People in the community tended to consume homegrown products.
The prevalence of ARM may be lower in this self-sustained farming community than elsewhere in the industrialized world.
报告意大利南部一个小型孤立社区萨兰德拉年龄相关性黄斑病变（ARM）的患病率，以检验这样一种假设，即一种在这种偏远社区稀缺但在现代工业社会普遍存在的环境因素可能会改变患ARM的风险。
基于人群的横断面调查。
通过眼底生物显微镜检查和30度立体黄斑摄影定义的晚期年龄相关性黄斑变性（ARMD）（地图样萎缩或渗出性黄斑病变）和ARM（大的软性玻璃膜疣或视网膜色素上皮改变，或两者皆有）的患病率。通过对参与者和当地商店零售商的访谈评估自给自足情况。使用一个将遗传群体结构与社区姓氏频率分布相拟合的模型计算遗传隔离程度。
576名符合条件的参与者中有366名（63.5%）接受了全面眼科检查，其中354名（96.7%）进行了ARMD存在情况的临床或摄影评估，310名（84.6%）在彩色透明片上对玻璃膜疣特征进行了ARM分级。ARMD的总体患病率为1.1%。在4.5%的受试者中发现了直径大于50微米且数量超过10个的玻璃膜疣。87.2%的参与者出生于萨兰德拉，每位受试者的父母双方中77.3%也是如此。该社区的人们倾向于消费自家种植的产品。
在这个自给自足的农业社区，ARM的患病率可能低于工业化世界的其他地方。
