美国犹他州盐湖城四个医疗中心的β-溶血性链球菌对九种抗菌药物的敏感性

Susceptibility of beta-hemolytic streptococci to nine antimicrobial agents among four medical centers in Salt Lake City, Utah, USA.

作者信息

Carroll K C, Monroe P, Cohen S, Hoffman M, Hamilton L, Korgenski K, Reimer L, Classen D, Daly J

机构信息

Department of Pathology, University of Utah Health Sciences Center, Salt Lake City 84132, USA.

出版信息

Diagn Microbiol Infect Dis. 1997 Apr;27(4):123-8. doi: 10.1016/s0732-8893(97)00025-4.

DOI:10.1016/s0732-8893(97)00025-4

PMID:9154408

Abstract

A multicenter study was performed to evaluate the susceptibility of beta-hemolytic streptococci to nine antimicrobial agents. MICs were performed in cation-supplemented Mueller-Hinton broth with 3.5% lysed sheep red blood cells according to NCCLS guidelines. A total of 646 isolates were tested: 300 (46%) group A; 170 (26%) group B; 38 (6%) group C, 35 (5%) group F; 83 (17%) group G; and 20 (3%) nongroupable. Six percent of the total isolates were resistant to one or more of the antibiotics tested. Approximately 7% of 387 strains from the University of Utah Hospital and Clinics were resistant to erythromycin. Four isolates were resistant to clindamycin. Six strains (3%) from Primary Children's Medical Center (207 tested) were resistant to one or more of the macrolides. Resistance was rare at the LDS Hospital and the Salt Lake Veteran's Affairs Hospital. Overall, resistance among beta-hemolytic streptococci in this geographic location does not seem to be a significant problem, except at the tertiary care university hospital.

摘要

进行了一项多中心研究，以评估β-溶血性链球菌对九种抗菌药物的敏感性。根据美国国家临床实验室标准委员会（NCCLS）的指南，在添加阳离子的Mueller-Hinton肉汤中加入3.5%溶解的绵羊红细胞进行最低抑菌浓度（MIC）检测。共检测了646株分离株：A组300株（46%）；B组170株（26%）；C组38株（6%），F组35株（5%）；G组83株（17%）；不可分组的20株（3%）。总分离株中有6%对一种或多种测试抗生素耐药。犹他大学医院和诊所的387株菌株中约7%对红霉素耐药。4株分离株对克林霉素耐药。在 Primary Children's Medical Center检测的207株菌株中有6株（3%）对一种或多种大环内酯类药物耐药。在LDS医院和盐湖退伍军人事务医院耐药情况罕见。总体而言，除了三级护理大学医院外，该地理位置的β-溶血性链球菌耐药似乎不是一个重大问题。