Frape D L, Williams N R, Scriven A J, Palmer C R, O'Sullivan K, Fletcher R J
N.S. Research, Suffolk.
Br J Nutr. 1997 Apr;77(4):523-35. doi: 10.1079/bjn19970054.
An experiment was conducted in twelve healthy middle-aged volunteers, six of each sex, with a mean BMI of 27 kg/m2 to detect differences between morning and afternoon in postprandial blood glucose, insulin and C-peptide concentrations. These responses were measured following the consumption of isoenergetic meals that were high or low in fat content, at breakfast and at lunch. Over 4 d each subject received the high-carbohydrate (L, 5.5 g mixed fat/meal) and moderately high-fat (M, 33 g mixed fat/meal) breakfasts and lunches, in three combinations (LL, MM, LM), or they fasted at breakfast time and received a moderately high-fat lunch (NM), in three Latin squares. Each evening a standard meal was given. Plasma glucose, insulin and C-peptide responses were greater following L than M meals and within both MM and LL treatments insulin and C-peptide responses were greater following breakfast than following lunch. The incremental C-peptide response to a fatty lunch following a fast at breakfast time (NM) was similar to that to a fatty breakfast, but the incremental insulin response for the same comparison was marginally lower at lunch (P = 0.06). The relationship of C-peptide and insulin concentrations was assessed. Plasma glucose response to a fatty lunch was increased by a fatty breakfast. The relationships of these metabolic events with fat metabolism are discussed.
在12名健康的中年志愿者中进行了一项实验，男女各6名，平均体重指数为27kg/m²，以检测餐后血糖、胰岛素和C肽浓度在上午和下午之间的差异。这些反应是在早餐和午餐时食用脂肪含量高或低的等能量餐后进行测量的。在4天内，每个受试者以三种组合（LL、MM、LM）接受高碳水化合物（L，每餐5.5g混合脂肪）和中度高脂肪（M，每餐33g混合脂肪）的早餐和午餐，或者他们在早餐时禁食并接受中度高脂肪午餐（NM），采用三个拉丁方设计。每天晚上提供一顿标准餐。L餐之后的血浆葡萄糖、胰岛素和C肽反应比M餐更大，并且在MM和LL两种处理中，早餐后的胰岛素和C肽反应比午餐后更大。早餐时禁食后（NM），高脂肪午餐后的C肽增量反应与高脂肪早餐后的相似，但相同比较下午餐时的胰岛素增量反应略低（P = 0.06）。评估了C肽和胰岛素浓度之间的关系。高脂肪早餐会增加对高脂肪午餐的血浆葡萄糖反应。讨论了这些代谢事件与脂肪代谢的关系。
