• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Thymus dependence of the IgG response: role of T cells is restricted to non-specific rather than antigen-specific factors.IgG应答的胸腺依赖性：T细胞的作用仅限于非特异性而非抗原特异性因素。
Immunology. 1979 Jul;37(3):603-8.
2
Non-specific factor replaces T cells in an IgG response to soluble antigens.在对可溶性抗原的IgG应答中，非特异性因子替代了T细胞。
Immunology. 1977 Sep;33(3):321-9.
3
Clonal anergy of memory B cells in epitope-specific regulation.表位特异性调节中记忆B细胞的克隆无能
J Immunol. 1990 Oct 15;145(8):2397-405.
4
T cell regulation of antibody responses: an I-A-specific, autoreactive T cell collaborates with antigen-specific helper T cells to promote IgG responses.
J Immunol. 1985 Feb;134(2):691-4.
5
Role of antigen-specific T cell help in the generation of in vivo antibody responses. I. Antigen-specific T cell help is required to generate a polyclonal IgG1 response in anti-IgD antibody-injected mice.抗原特异性T细胞辅助在体内抗体应答产生中的作用。I. 在注射抗IgD抗体的小鼠中，产生多克隆IgG1应答需要抗原特异性T细胞辅助。
J Immunol. 1992 Dec 15;149(12):3836-44.
6
Role of antigen-specific B cells in the induction of SRBC-specific T cell proliferation.抗原特异性B细胞在诱导抗绵羊红细胞特异性T细胞增殖中的作用。
J Immunol. 1984 May;132(5):2253-8.
7
Role of antigen-specific T cell help in the generation of in vivo antibody responses. II. Sustained antigen-specific T cell help is required to induce a specific antibody response.抗原特异性T细胞辅助在体内抗体应答产生中的作用。II. 诱导特异性抗体应答需要持续的抗原特异性T细胞辅助。
J Immunol. 1992 Dec 15;149(12):3845-50.
8
Limiting dilution analysis of helper T-cell function.辅助性T细胞功能的有限稀释分析。
Immunology. 1975 Jun;28(6):1135-48.
9
Antigen-specific suppressor T cell interactions. I. Induction of an MHC-restricted suppressor factor specific for L-glutamic acid50-L-tyrosine50.抗原特异性抑制性T细胞相互作用。I. 对L-谷氨酸50-L-酪氨酸50特异的MHC限制性抑制因子的诱导。
J Immunol. 1982 Jun;128(6):2447-52.
10
Antigen-initiated B lymphocyte differentiation. Kinetics and T lymphocyte dependence of the primary and secondary in vitro immune responses to the hapten 4-hydroxy-3-iodo-5-nitrophenylacetic acid presented on the carrier polymerised bacterial flagellin.抗原引发的B淋巴细胞分化。对载体聚合细菌鞭毛蛋白上呈现的半抗原4-羟基-3-碘-5-硝基苯乙酸的初次和二次体外免疫反应的动力学及T淋巴细胞依赖性。
Aust J Exp Biol Med Sci. 1974 Jun;52(Pt 3):471-89.

本文引用的文献

1
Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen.抗三硝基苯基（TNP）空斑试验。Balb/c小鼠对可溶性和颗粒性免疫原的初次反应。
Proc Soc Exp Biol Med. 1969 Nov;132(2):575-81. doi: 10.3181/00379727-132-34264.
2
Brain-associated theta antigen: reactivity of rabbit anti-mouse brain with mouse lymphoid cells.脑相关θ抗原：兔抗小鼠脑与小鼠淋巴细胞的反应性。
Cell Immunol. 1971 Aug;2(4):353-61. doi: 10.1016/0008-8749(71)90070-0.
3
Soluble mediators of T-B interaction.T细胞与B细胞相互作用的可溶性介质
Eur J Immunol. 1973 Oct;3(10):650-2. doi: 10.1002/eji.1830031012.
4
In vitro anti-hapten response to a lactoside-conjugated protein.
Cell Immunol. 1975 Sep;19(1):117-28. doi: 10.1016/0008-8749(75)90296-8.
5
IgG response in vitro. I. The requirement for an intermediate responsive cell type.体外IgG反应。I. 对中间反应性细胞类型的需求。
Eur J Immunol. 1976 Jan;6(1):8-15. doi: 10.1002/eji.1830060104.
6
A simplified method for the in vitro induction of IgG antibody in collagen coated dishes.一种在胶原包被培养皿中体外诱导IgG抗体的简化方法。
Immunology. 1978 Jun;34(6):1071-6.
7
IgG anti-hapten antibody secretion in vitro commences after extensive precursor proliferation.体外IgG抗半抗原抗体分泌在大量前体细胞增殖后开始。
Immunology. 1977 Oct;33(4):485-90.
8
Conditions for the development of IgM- and IgG-antibody-secreting cells from primed mouse splenocytes in vitro.体外从小鼠致敏脾细胞发育IgM和IgG抗体分泌细胞的条件。
Immunology. 1977 May;32(5):793-801.
9
Mechanism of T-cell help in the immune response to soluble protein antigens II. Reconstitution of primary and secondary in vitro immune responses to dinitrophenyl-carrier conjugates by T-cell-replacing factor.T细胞辅助可溶性蛋白抗原免疫应答的机制II. 用T细胞替代因子重建对二硝基苯基-载体偶联物的初次和二次体外免疫应答
J Exp Med. 1977 May 1;145(5):1228-36. doi: 10.1084/jem.145.5.1228.
10
Non-specific factor replaces T cells in an IgG response to soluble antigens.在对可溶性抗原的IgG应答中，非特异性因子替代了T细胞。
Immunology. 1977 Sep;33(3):321-9.

IgG应答的胸腺依赖性：T细胞的作用仅限于非特异性而非抗原特异性因素。

Thymus dependence of the IgG response: role of T cells is restricted to non-specific rather than antigen-specific factors.

作者信息

Kemshead J T, Askonas B A

出版信息

Immunology. 1979 Jul;37(3):603-8.

PMID:91574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1457725/
Abstract

We have been studying the requirement for T cells in the proliferation and maturation of partially differentiated memory cells into IgG antibody secreting cells. The role of T cells in such a system can be replaced by non-antigen-specific T-cell factor(s) present in the supernatant of a 24 h mixed lymphocyte reaction (TRF) but not by antigen-specific factors released upon in vitro induction of T-helper cells with antigen. A combination of antigen-specific and non-specific factors showed no evidence of synergy between the two sets of factors and we therefore conclude that the antigen-specific factors tested play no role in the later stages of B-memory cell maturation to IgG-antibody secreting cells.

摘要

我们一直在研究T细胞在部分分化的记忆细胞增殖以及成熟为分泌IgG抗体的细胞过程中的需求。在这样一个系统中，T细胞的作用可被存在于24小时混合淋巴细胞反应上清液中的非抗原特异性T细胞因子（TRF）所取代，而不能被体外抗原诱导T辅助细胞释放的抗原特异性因子所取代。抗原特异性因子和非特异性因子的组合未显示出两组因子之间有协同作用的证据，因此我们得出结论，所测试的抗原特异性因子在B记忆细胞成熟为分泌IgG抗体的细胞的后期阶段不起作用。