Teng L, Bruce R B, Dunning L K
J Pharm Sci. 1977 Nov;66(11):1615-8. doi: 10.1002/jps.2600661128.
A high-pressure liquid chromatographic method suitable for determining plasma metoclopramide levels at normal (10-20 mg) doses is described. Eight metabolites as well as metclopramide were isolated and identified in rat, dog. and human urine. The only common metabolite in these species is 2-[(4-amino-5-chloro-2-methoxybenzoyl)-amino] acetic acid. N-Deethylation is a major pathway for metoclopramide metabolism in the lower animals but not in humans. Metoclopramide is excreted mainly unchanged or as its conjugates by humans.
本文描述了一种适用于测定正常（10 - 20毫克）剂量血浆中甲氧氯普胺水平的高压液相色谱法。在大鼠、狗和人类尿液中分离并鉴定出了八种代谢物以及甲氧氯普胺。这些物种中唯一的常见代谢物是2 - [(4 - 氨基 - 5 - 氯 - 2 - 甲氧基苯甲酰基) - 氨基]乙酸。N - 去乙基化是甲氧氯普胺在低等动物体内代谢的主要途径，但在人类中并非如此。甲氧氯普胺在人体内主要以原形或其结合物形式排泄。
