Mielke G, Dietz K, Franz H, Reiss I, Gembruch U
Department of Obstetrics and Gynaecology, University of Tübingen, Germany.
Prenat Diagn. 1997 Apr;17(4):323-6.
Several syndromes and aneuploidies are associated with ocular abnormalities including up- and down-slanting palpebral fissures. We describes a technique for the sonographic assessment of the fetal palpebral fissure slant which was used in 70 normal pregnancies from 14 to 36 weeks of gestation. In a frontal view of the fetal face, the inferior angle between the palpebral fissure and the midline of the skull was determined. The median angle was 89 degrees, with a range from 87 degrees to 90 degrees. In selected cases, sonographic assessment of the fetal palpebral fissure slant may be a helpful additional tool in the prenatal diagnosis of syndromes, as demonstrated in a fetus with Seckel syndrome associated with downslanting palpebral fissures and in a fetus with Down's syndrome associated with upslanting palpebral fissures.
几种综合征和非整倍体与眼部异常有关，包括睑裂向上和向下倾斜。我们描述了一种用于超声评估胎儿睑裂倾斜度的技术，该技术应用于70例妊娠14至36周的正常孕妇。在胎儿面部的正视图中，确定睑裂与颅骨中线之间的下角。中位角度为89度，范围为87度至90度。在某些病例中，超声评估胎儿睑裂倾斜度可能是产前诊断综合征的一种有用的辅助工具，如在一例患有与睑裂向下倾斜相关的塞克尔综合征的胎儿以及一例患有与睑裂向上倾斜相关的唐氏综合征的胎儿中所证明的那样。
