Yamamoto T, Moriwaki Y, Takahashi S, Yamakita J, Tsutsumi Z, Ohata H, Hiroishi K, Nakano T, Higashino K
Third Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
Metabolism. 1997 May;46(5):544-7. doi: 10.1016/s0026-0495(97)90192-x.
To determine whether both ethanol and fructose increase the plasma concentration of uridine, we administered ethanol (0.6 g/kg) or fructose (1.0 g/kg) to seven normal subjects. Both ethanol and fructose increased the plasma concentration of uridine together with an increase in the plasma concentration of oxypurines, whereas fructose also increased the plasma concentration of uric acid, but ethanol did not. In ethanol ingestion and fructose infusion, an increase in the plasma concentration of purine bases correlated with that of uridine. These results strongly suggest that an increase in the plasma concentration of uridine is ascribable to increased pyrimidine degradation following purine degradation increased by ethanol and fructose.
为了确定乙醇和果糖是否都会增加血浆中尿苷的浓度，我们对7名正常受试者给予乙醇（0.6 g/kg）或果糖（1.0 g/kg）。乙醇和果糖均使血浆中尿苷的浓度升高，同时氧化嘌呤的血浆浓度也升高，而果糖还使尿酸的血浆浓度升高，但乙醇没有。在摄入乙醇和输注果糖的过程中，嘌呤碱血浆浓度的升高与尿苷的升高相关。这些结果有力地表明，血浆中尿苷浓度的升高归因于乙醇和果糖使嘌呤降解增加后嘧啶降解的增加。
