Le Corre S, Sharp T, Young A H, Harrison P J
University Department of Neuropathology, Radcliffe Infirmary, Oxford, UK.
Psychopharmacology (Berl). 1997 Apr;130(4):368-74. doi: 10.1007/s002130050252.
The brain 5-HT (serotonin) system and circulating corticosteroids are in close interaction and both are implicated in the pathogenesis of affective disorders. The 5-HT1A receptor is thought to play a major role in this relationship. However, the recently cloned 5-HT7 receptor may also be involved, given its pharmacological similarities to the 5-HT1A receptor and its high expression in corticolimbic structures. Using in situ hybridization histochemistry, we have investigated 5-HT7 and 5-HT1A receptor mRNA expression in selected areas of the rat brain 7 days post-adrenalectomy. 5-HT7 receptor mRNA was increased in CA1 and CA3b after adrenalectomy, with no alterations in other hippocampal subfields or in retrosplenial cortex. Adrenalectomy was associated with a marked increase of 5-HT1A receptor mRNA in dentate gyrus, CA3 and CA2, but not in CA1, nor in the raphe. These data indicate that circulating adrenal steroids have a inhibitory role on the expression of hippocampal 5-HT7 receptors as well as 5-HT1A receptors, but the effect upon the two transcripts occurs in different subfields. The 5-HT7 receptor is an additional candidate for mediating the interactions between 5-HT and corticosteroids within the hippocampus.
大脑5-羟色胺（血清素）系统与循环中的皮质类固醇密切相关，二者均与情感障碍的发病机制有关。5-羟色胺1A受体被认为在这种关系中起主要作用。然而，鉴于其与5-羟色胺1A受体在药理学上的相似性及其在皮质边缘结构中的高表达，最近克隆出的5-羟色胺7受体可能也参与其中。我们采用原位杂交组织化学方法，研究了大鼠肾上腺切除术后7天，其大脑特定区域中5-羟色胺7受体和5-羟色胺1A受体mRNA的表达情况。肾上腺切除术后，CA1和CA3b区域的5-羟色胺7受体mRNA增加，而海马体其他亚区或压后皮质无变化。肾上腺切除术与齿状回、CA3和CA2区域中5-羟色胺1A受体mRNA的显著增加相关，但CA1区域和中缝核未出现这种情况。这些数据表明，循环中的肾上腺类固醇对海马体5-羟色胺7受体以及5-羟色胺1A受体的表达具有抑制作用，但对这两种转录本的影响发生在不同的亚区。5-羟色胺7受体是介导海马体内5-羟色胺与皮质类固醇相互作用的另一个候选因素。
