Ben-Aryeh H, Jungerman T, Szargel R, Klein E, Laufer D
Laboratory of Oral Biology, Department of Oral and Maxillofacial Surgery, Rambam Medical Center, Haifa, Israel.
Biol Psychiatry. 1996 Jun 1;39(11):946-9. doi: 10.1016/0006-3223(95)00296-0.
The extent of hypersalivation was evaluated in a group of 25 schizophrenic patients on clozapine. A high prevalence of the complaint was detected by a questionnaire; up to 80% of the patients complained of hypersalivation at night. Salivary flow-rate and composition was examined in 17 patients who agreed to participate and in a matched group of healthy controls. No significant differences were detected in composition or flow-rates of resting and stimulated saliva. The salivary flow-rates in the schizophrenic patients on clozapine did not correlate with the subjective complaint of hypersalivation. Because the severity and prevalence of the complaint was higher at night, a possibility of an altered circadian rhythm of salivation might be suggested in these patients.
对一组25名服用氯氮平的精神分裂症患者的流涎程度进行了评估。通过问卷调查发现该症状的患病率很高；高达80%的患者抱怨夜间流涎。对17名同意参与的患者以及一组匹配的健康对照者进行了唾液流速和成分检测。静息和刺激唾液的成分或流速均未检测到显著差异。服用氯氮平的精神分裂症患者的唾液流速与流涎的主观主诉不相关。由于该症状在夜间的严重程度和患病率更高，因此可能提示这些患者的唾液分泌昼夜节律发生了改变。
