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巴西神经囊尾蚴病的流行病学

Epidemiology of neurocysticercosis in Brazil.

作者信息

Agapejev S

机构信息

Department of Neurology, School of Medicine, State University of São Paulo (UNESP), Brazil.

出版信息

Rev Inst Med Trop Sao Paulo. 1996 May-Jun;38(3):207-16. doi: 10.1590/s0036-46651996000300008.

DOI:10.1590/s0036-46651996000300008
PMID:9163986
Abstract

A revision of literature was done with the objective of tracing an epidemiologic profile of neurocysticercosis (NCC) in Brazil. The prevalence was 0.12-9% in autopsies. The frequency was 0.03-7.5% in clinical series and 0.68-5.2% in seroepidemiological studies. The disease corresponds to 0.08-2.5% of admissions to general hospitals. Patient origin was rural in 30-63% of cases. The most involved age range (64-100%) was 11 to 60 years, with a predominance (22-67%) between 21 and 40 years. The male sex was the most affected (51-80%). In the severe forms there was a predominance of urban origin (53-62%) and of the female sex (53-75%). The period of hospitalization ranges from 1 to 254 days and 33 to 50% of patients suffer 1.7 +/- 1.4 admissions. The clinical picture was variable, with a predominance of epileptic syndrome (22-92%) and intracranial hypertension (19-89%). Psychiatric manifestations were associated in 9-23% of patients. Lethality was 0.29% in terms of all diseases in general and 4.8-25.9% in terms of neurologic diseases. The asymptomatic form was detected in 6% of patients in clinical series and in 48.5% of case from autopsies. The racemose form and ventricular localization also was observed as asymptomatic form. Among the patients with cutaneous cysticercosis 65% of them showed neurologic manifestations.

摘要

为追踪巴西神经囊尾蚴病(NCC)的流行病学概况,我们对文献进行了回顾。尸检中的患病率为0.12%-9%。临床系列研究中的发病率为0.03%-7.5%,血清流行病学研究中的发病率为0.68%-5.2%。该疾病占综合医院入院人数的0.08%-2.5%。30%-63%的病例患者来自农村。最常受累的年龄范围(64%-100%)为11至60岁,其中21至40岁的人群占主导(22%-67%)。男性受影响最为严重(51%-80%)。在严重病例中,城市居民(53%-62%)和女性(53%-75%)占多数。住院时间从1天到254天不等,33%-50%的患者平均住院1.7±1.4次。临床表现多样,以癫痫综合征(22%-92%)和颅内高压(19%-89%)为主。9%-23%的患者伴有精神症状。总体而言,所有疾病的致死率为0.29%,神经系统疾病的致死率为4.8%-25.9%。临床系列研究中6%的患者以及尸检病例中48.5%的患者被检测出无症状感染。葡萄状和脑室型囊尾蚴病也可表现为无症状感染。皮肤囊尾蚴病患者中,65%出现神经系统症状。

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