Perry P J, MacIndoe J H, Yates W R, Scott S D, Holman T L
Department of Psychiatry, College of Medicine, University of Iowa, Iowa City 52246, USA.
Clin Chem. 1997 May;43(5):731-5.
Our goal in this study was to determine whether the urinary ratio of testosterone to luteinizing hormone (T/LH) as an indicator of exogenous anabolic steroid (AS) use is superior to the urinary ratio of testosterone to epitestosterone (T/E). After 2 weekly placebo injections, 19 subjects were given testosterone cypionate (TC) injections of 250 or 500 mg/week for 14 weeks followed by 14 weekly placebo injections. Patients were considered to have ceased taking TC if they tested negative 9 weeks after their last injection. For detection of illicit or supraphysiological TC (AS) use, the urinary T/E ratio of > or = 6 yielded a false-negative rate of 46% and a false-positive rate of 4%. However, a urinary T/LH ratio of > or = 30 produced a false-negative rate of only 24% and a false-positive rate of 13%. We conclude that the urinary T/LH ratio of > or = 30 is a more sensitive marker of AS use than the urinary T/E ratio of > or = 6 and remains sensitive for twice as long as urinary T/E.
本研究的目的是确定作为外源性合成代谢类固醇（AS）使用指标的尿睾酮与促黄体生成素比值（T/LH）是否优于尿睾酮与表睾酮比值（T/E）。在进行2周的安慰剂注射后，19名受试者接受每周250或500mg的环戊丙酸睾酮（TC）注射，持续14周，随后进行14周的每周安慰剂注射。如果患者在最后一次注射后9周检测呈阴性，则认为他们已停止服用TC。为检测非法或超生理剂量的TC（AS）使用情况，尿T/E比值≥6时，假阴性率为46%，假阳性率为4%。然而，尿T/LH比值≥30时，假阴性率仅为24%，假阳性率为13%。我们得出结论，尿T/LH比值≥30是比尿T/E比值≥6更敏感的AS使用标志物，且其敏感性持续时间是尿T/E的两倍。
