ERS-24，一种参与内质网和高尔基体之间囊泡运输的哺乳动物v-SNARE蛋白。
ERS-24, a mammalian v-SNARE implicated in vesicle traffic between the ER and the Golgi.
作者信息
Paek I, Orci L, Ravazzola M, Erdjument-Bromage H, Amherdt M, Tempst P, Söllner T H, Rothman J E
机构信息
Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York 10021, USA.
出版信息
J Cell Biol. 1997 Jun 2;137(5):1017-28. doi: 10.1083/jcb.137.5.1017.
We report the identification and characterization of ERS-24 (Endoplasmic Reticulum SNARE of 24 kD), a new mammalian v-SNARE implicated in vesicular transport between the ER and the Golgi. ERS24 is incorporated into 20S docking and fusion particles and disassembles from this complex in an ATP-dependent manner. ERS-24 has significant sequence homology to Sec22p, a v-SNARE in Saccharomyces cerevisiae required for transport between the ER and the Golgi. ERS-24 is localized to the ER and to the Golgi, and it is enriched in transport vesicles associated with these organelles.
我们报告了ERS-24（24kD内质网SNARE）的鉴定和特性，它是一种新的哺乳动物v-SNARE，参与内质网和高尔基体之间的囊泡运输。ERS24被整合到20S对接和融合颗粒中，并以ATP依赖的方式从该复合物中解离。ERS-24与Sec22p具有显著的序列同源性，Sec22p是酿酒酵母中内质网和高尔基体之间运输所需的v-SNARE。ERS-24定位于内质网和高尔基体，并且在与这些细胞器相关的运输小泡中富集。
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