一种参与高尔基体内运输的v-SNARE蛋白。
A v-SNARE implicated in intra-Golgi transport.
作者信息
Nagahama M, Orci L, Ravazzola M, Amherdt M, Lacomis L, Tempst P, Rothman J E, Söllner T H
机构信息
Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, New York 10021, USA.
出版信息
J Cell Biol. 1996 May;133(3):507-16. doi: 10.1083/jcb.133.3.507.
Abstract
We report the identification of a putative v-SNARE (GOS-28), localized primarily to transport vesicles at the terminal rims of Golgi stacks. In vitro, GOS-28, A Golgi SNARE of 28 kD, is efficiently packaged into Golgi-derived vesicles, which are most likely COPI coated. Antibodies directed against GOS-28 block its ability to bind alpha-SNAP, partially inhibit transport from the cis to the medial cisternae, and do not inhibit budding of COP-coated vesicles, but do accumulate docked uncoated vesicles.
摘要
我们报告了一种假定的v-SNARE（GOS-28）的鉴定结果，其主要定位于高尔基体堆栈末端边缘的运输小泡。在体外，28kD的高尔基体SNARE GOS-28能高效地包装到源自高尔基体的小泡中，这些小泡很可能被COP I包被。针对GOS-28的抗体阻断其与α-SNAP结合的能力，部分抑制从顺面到中间潴泡的运输，不抑制COP包被小泡的出芽，但会使停靠的无包被小泡积累。
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