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解脂耶氏酵母这种双态真菌的生理学与遗传学

Physiology and genetics of the dimorphic fungus Yarrowia lipolytica.

作者信息

Barth G, Gaillardin C

机构信息

Institut für Mikrobiologie, Technische Universität Dresden, Germany.

出版信息

FEMS Microbiol Rev. 1997 Apr;19(4):219-37. doi: 10.1111/j.1574-6976.1997.tb00299.x.

DOI:10.1111/j.1574-6976.1997.tb00299.x
PMID:9167256
Abstract

The ascomycetous yeast Yarrowia lipolytica (formerly Candida, Endomycopsis, or Saccharomyces lipolytica) is one of the more intensively studied 'non-conventional' yeast species. This yeast is quite different from the well-studied yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe with respect to its phylogenetic evolution, physiology, genetics, and molecular biology. However, Y. lipolytica is not only of interest for fundamental research, but also for biotechnological applications. It secretes several metabolites in large amounts (i.e. organic acids, extracellular proteins) and the tools are available for overproduction and secretion of foreign proteins. This review presents a comprehensive overview on the available data on physiology, cell biology, molecular biology and genetics of Y. lipolytica.

摘要

解脂耶氏酵母(以前称为解脂假丝酵母、解脂内孢霉或解脂酿酒酵母)是研究较为深入的“非常规”酵母物种之一。就其系统发育进化、生理学、遗传学和分子生物学而言,这种酵母与已得到充分研究的酿酒酵母和粟酒裂殖酵母有很大不同。然而,解脂耶氏酵母不仅在基础研究方面具有重要意义,在生物技术应用方面也备受关注。它能大量分泌多种代谢产物(如有机酸、细胞外蛋白质),并且具备用于过量生产和分泌外源蛋白质的工具。本文综述了有关解脂耶氏酵母生理学、细胞生物学、分子生物学和遗传学的现有数据。

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