同卵双胞胎中的镜像视神经发育不良伴相关屈光参差。
Mirror-image optic nerve dysplasia with associated anisometropia in identical twins.
作者信息
Cidis M B, Warshowsky J H, Goldrich S G, Meltzer C C
机构信息
State University of New York, State College of Optometry, New York 10010, USA.
出版信息
J Am Optom Assoc. 1997 May;68(5):325-9.
BACKGROUND
Monozygotic (MZ) or "identical" twins arise from a single fertilized egg, which divides into two embryos at an early stage of development. As a result, MZ twins have identical genomes and are always of the same sex.
METHODS
A case of optic nerve hypoplasia and anisometropia, in association with mirror-image presentation in a set of 12-year-old identical twins, is reported. The monozygotic twinning event responsible for identical twins--as well as the rare phenomenon of mirror imaging--is described.
RESULTS
The combined occurrence of anisometropia and optic nerve hypoplasia in mirror-image presentation in a set of monozygotic twins provides a unique opportunity to study the genetic versus environmental influences on the development of optic nerve hypoplasia.
CONCLUSIONS
Although the cause of optic nerve hypoplasia remains unclear, its associated mirror-image presentation in this case suggests a possible genetic predisposition.
背景
同卵双胞胎源自单个受精卵，该受精卵在发育早期分裂为两个胚胎。因此，同卵双胞胎具有相同的基因组，且性别总是相同。
方法
报告了一例12岁同卵双胞胎出现视神经发育不全、屈光参差并伴有镜像现象的病例。描述了导致同卵双胞胎的单卵双胎事件以及罕见的镜像现象。
结果
同卵双胞胎出现屈光参差和视神经发育不全并伴有镜像现象，为研究遗传因素与环境因素对视神经发育不全的影响提供了独特的机会。
结论
虽然视神经发育不全的病因尚不清楚，但该病例中与之相关的镜像现象提示可能存在遗传易感性。
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