Kotchen T A, Welch W J, Daugherty M, Ernst C B
Nephron. 1977;19(4):228-35. doi: 10.1159/000180893.
Plasma renin reactivity (PRR) is the in vitro rate of angiotensin generation after addition of exogenous renin to plasma. The purpose of the present study is to compare measurements of PRR in venous effluent from the involved and uninvolved kidneys in both experimental and clinical renovascular hypertension. A two-kidney model of experimental hypertension was created by placing an ameroid resin constrictor around one renal artery in each of seven dogs. Plasma renin activity (PRA) in venous plasma from the involved kidney increased (p less than 0.001); comparing PRA in venous effluent from the stenotic and nonstenotic kidneys, the PRA ratio also increased ( p less than 0.005). Renal venous PRR did not change on either side after occlusion of the renal artery (p greater than 0.1), and the renal venous PRR ratio did not differ from the mean control ratio of 1.0 +/- 1 SE (p greater than 0.1). Similarly, in 9 patients with renovascular hypertension, mean PRR in venous plasma from the two kidneys did not differ (p greater than 0.8). These results suggest that measurement of renal venous PRR is not helpful in confirming a diagnosis of renovascular hypertension.
血浆肾素反应性（PRR）是指在血浆中加入外源性肾素后血管紧张素生成的体外速率。本研究的目的是比较实验性和临床肾血管性高血压中患侧肾脏和未患侧肾脏静脉流出液中PRR的测量值。通过在7只狗的每只狗的一条肾动脉周围放置一个阿梅洛德树脂收缩器，建立了一种双肾实验性高血压模型。患侧肾脏静脉血浆中的血浆肾素活性（PRA）升高（p<0.001）；比较狭窄肾脏和非狭窄肾脏静脉流出液中的PRA，PRA比值也升高（p<0.005）。肾动脉闭塞后，两侧的肾静脉PRR均无变化（p>0.1），且肾静脉PRR比值与平均对照比值1.0±1 SE无差异（p>0.1）。同样，在9例肾血管性高血压患者中，两侧肾脏静脉血浆中的平均PRR无差异（p>0.8）。这些结果表明，测量肾静脉PRR无助于确诊肾血管性高血压。
