Corey L, Rubin R J, Bregman D, Gregg M B
Pediatrics. 1977 Nov;60(5):702-8.
Between December 15, 1973, and Jun 30, 1974, a total of 379 cases of Reye's syndrome was reported to the Center for Disease Control. One hundred forty-seven (40%) were confirmed by either autopsy or biopsy, while 232 were diagnosed by clinical and laboratory parameters. Comparisons of the epidemiologic and demographic characteristics, the hospital course, the outcome, and the laboratory abnormalities of the clinically diagnosed and the pathologically confirmed cases revealed no significant differences. In the epidemiologic setting of influenza B outbreaks, children who have the acute onset of noninflammatory encephalopathy associated with elevated serum transaminase levels, hypoprothrombinemia, and elevated blood ammonia levels should be considered to have Reye's syndrome. Further evaluation of diagnostic criteria is needed, however, for sporadically occurring, nonepidemic cases of noninflammatory encephalopathy associated with hepatic dysfunction.
在1973年12月15日至1974年6月30日期间，疾病控制中心共收到379例瑞氏综合征的报告。其中147例（40%）经尸检或活检确诊，232例通过临床和实验室指标诊断。对临床诊断病例和病理确诊病例的流行病学和人口统计学特征、住院病程、转归以及实验室异常情况进行比较，未发现显著差异。在乙型流感暴发的流行病学背景下，对于急性起病、伴有血清转氨酶水平升高、凝血酶原血症及血氨水平升高的非炎性脑病患儿，应考虑为瑞氏综合征。然而，对于散发性、非流行性的伴有肝功能障碍的非炎性脑病病例，还需要进一步评估诊断标准。
