Davis J D, Smith G P, Sayler J L
E. W. Bourne Behavioral Research Laboratory, New York Hospital-Cornell Medical Center, White Plains 10605, USA.
Am J Physiol. 1997 May;272(5 Pt 2):R1599-605. doi: 10.1152/ajpregu.1997.272.5.R1599.
With two exceptions, the literature shows that confining ingested fluid to the stomach of a rat during an intake test had no effect on the volume ingested. In the two exceptions (J. D. Davis and J. L. Sayler, Physiol. Behav. In press. J. A. Deutsch, Handbook of Behavioral Neurobiology. Neurobiology of Food and Fluid Intake, edited by E. M. Stricker. New York: Plenum, 1990, vol. 10), intake with the cuff open was very large, suggesting that, when intake on cuff-open tests exceeds some critical volume, confining all of it to the stomach during the test will reduce intake. To test this, we measured intake of three different solutions known to stimulate large intake with the pylorus open and closed. In cuff-closed tests, intake was less than in cuff-open tests. In cuff-closed tests, rate of licking began to decline within 5-6 min when only about one-quarter of the ultimate contents of the stomach had accumulated, indicating that some signal from the stomach slowed the rate of ingestion before the full capacity of the stomach was reached. This shows that the stomach is sensitive to its contents when it contains only a small proportion of its capacity.
有两个例外情况，文献表明在摄入测试期间将摄入的液体限制在大鼠胃内对摄入量没有影响。在这两个例外情况中（J.D. 戴维斯和J.L. 塞勒，《生理学与行为》，即将发表。J.A. 多伊奇，《行为神经生物学手册。食物和液体摄入的神经生物学》，E.M. 斯特里克编辑。纽约：普伦蒂斯出版社，1990年，第10卷），袖带打开时的摄入量非常大，这表明，当袖带打开测试中的摄入量超过某个临界体积时，在测试期间将所有液体限制在胃内会减少摄入量。为了验证这一点，我们测量了三种已知在幽门打开和关闭时会刺激大量摄入的不同溶液的摄入量。在袖带关闭的测试中，摄入量低于袖带打开的测试。在袖带关闭的测试中，当胃内仅积累了约四分之一的最终容量时，舔舐速率在5 - 6分钟内开始下降，这表明在胃达到其全部容量之前，来自胃的某种信号减缓了摄入速率。这表明当胃仅容纳其容量的一小部分时，胃对其内容物是敏感的。
