Shintani S, Alcalde R E, Matsumura T, Terakado N
Department of Oral and Maxillofacial Surgery II, Okayama University Dental School, Japan.
Cancer Lett. 1997 Jun 3;116(1):9-14. doi: 10.1016/s0304-3835(97)04730-7.
Adenoid cystic carcinoma (ACC) is a salivary malignant tumor with poor long-term prognosis, that is known to have predilection for invasion of the adjacent stroma and neural tissues. This carcinoma has shown a high incidence of recurrence and distal metastasis. Invasive carcinomas have been associated with the distributions of extracellular matrices (ECM). Cell proliferation as a marker of tumor growth has been related to poor prognosis in oral carcinomas. Immunohistochemical analysis of 15 cases of ACC was done using antibodies to laminin, type IV collagen, fibronectin, tenascin and anti-proliferating nuclear antigen (PCNA). Laminin and type IV collagen were totally or partially absent in the ACC invasive areas. Tenascin was expressed in the stroma and cytoplasm and was associated with tumor cell proliferation. It can be concluded that basement membrane represents a barrier that is lost during cell invasion and tenascin may be involved in the detachment of cancer cells, increasing the invasive potential of ACC.
腺样囊性癌（ACC）是一种长期预后较差的涎腺恶性肿瘤，已知其倾向于侵犯邻近的基质和神经组织。这种癌症具有较高的复发率和远处转移率。浸润性癌与细胞外基质（ECM）的分布有关。细胞增殖作为肿瘤生长的标志物，与口腔癌的不良预后相关。使用抗层粘连蛋白、IV型胶原、纤连蛋白、腱生蛋白和抗增殖细胞核抗原（PCNA）的抗体对15例ACC进行了免疫组织化学分析。层粘连蛋白和IV型胶原在ACC浸润区域完全或部分缺失。腱生蛋白在基质和细胞质中表达，并与肿瘤细胞增殖相关。可以得出结论，基底膜代表了细胞侵袭过程中丧失的屏障，腱生蛋白可能参与癌细胞的脱离，增加了ACC的侵袭潜能。
