Haegert D G, Coombs R R
Lancet. 1979 Nov 17;2(8151):1051-3. doi: 10.1016/s0140-6736(79)92446-2.
Human "null" lymphocytes have been recognised because they lack T-lymphocyte membrane markers and the surface membrane immunoglobulin (smIg), detectable by direct immunofluorescence, which conventionally characterises B lymphocytes. But almost all null lymphocytes express smIg determinants which are demonstrable by the direct antiglobulin and mixed antiglobulin rosette tests. It is argued that the definition of a B lymphocyte should be extended to include the null cells which react in these tests. If the heterogeneity of the B-lymphocyte population is more widely recognized, the precise nature of human natural and antibody-dependent killer cells may become clearer.
人类“裸”淋巴细胞已被识别，因为它们缺乏T淋巴细胞膜标志物以及通过直接免疫荧光可检测到的表面膜免疫球蛋白（smIg），而smIg是传统上用于表征B淋巴细胞的特征。但几乎所有裸淋巴细胞都表达smIg决定簇，这可通过直接抗球蛋白和混合抗球蛋白玫瑰花结试验得到证实。有人认为，B淋巴细胞的定义应扩大到包括在这些试验中产生反应的裸细胞。如果能更广泛地认识到B淋巴细胞群体的异质性，人类天然杀伤细胞和抗体依赖性杀伤细胞的确切性质可能会变得更加清晰。
