正常的CD5⁺ B淋巴细胞在自体混合淋巴细胞反应（AMLR）中是较弱的刺激细胞。
Normal CD5+ B lymphocytes are poor stimulators in the autologous mixed lymphocyte reaction (AMLR).
作者信息
Fernandez L A, Cheng R, Sadek I, Nevill T J, Macsween J M
机构信息
Department of Medicine, Dalhousie University, QEII Health Sciences Centre, Halifax, Nova Scotia, Canada.
出版信息
Clin Exp Immunol. 1997 Jun;108(3):557-61. doi: 10.1046/j.1365-2249.1997.3831280.x.
The AMLR is decreased in chronic lymphocytic leukaemia (CLL), which is characterized by a monoclonal expansion of CD5+ B lymphocytes. Since B cells are used to stimulate the AMLR, we investigated the capacity of normal CD5+ B cells to function as stimulators in the AMLR. We isolated B cells from the peripheral blood of normal individuals and fractionated them into subpopulations enriched for CD5+ and CD5- cells, which were used as stimulators in the AMLR. We found that the CD5- B cells were excellent stimulators, whereas stimulation of AMLR by B cells enriched for CD5+ cells resulted in significantly reduced proliferative responses (P < 0.005). This suggests that the reduced AMLR in CLL is due to the predominance of CD5+ B lymphocytes in the stimulating cell population.
慢性淋巴细胞白血病（CLL）患者的自体混合淋巴细胞反应（AMLR）降低，该病以CD5+B淋巴细胞的单克隆扩增为特征。由于B细胞用于刺激AMLR，我们研究了正常CD5+B细胞在AMLR中作为刺激细胞的能力。我们从正常个体的外周血中分离出B细胞，并将其分为富含CD5+和CD5-细胞的亚群，用作AMLR中的刺激细胞。我们发现，CD5-B细胞是极佳的刺激细胞，而富含CD5+细胞的B细胞刺激AMLR导致增殖反应显著降低（P<0.005）。这表明CLL中AMLR降低是由于刺激细胞群体中CD5+B淋巴细胞占主导地位。
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