Gupta S, Chandy G, Thornton M, Goldberg M
J Clin Immunol. 1985 May;5(3):187-94. doi: 10.1007/BF00915510.
In this study we have demonstrated that in the T-TA autologous mixed lymphocyte reaction (AMLR), OKT4+ T cells are the major responders; however, in the presence of additional interleukin-2 (IL-2), OKT8+ T cells also respond by proliferation. Both OKT4+ and OKT8+ T cells, activated in the T-non-T AMLR, act as stimulators in the T-TA AMLR. OKT4+ T cells activated in the T-TA AMLR suppress the proliferative response of the fresh T-non-T AMLR; control OKT4+ cells show no immunoregulatory activity in this system. In contrast, control OKT8+ T cells spontaneously suppress the proliferation of the T-non-T AMLR, but activation of OKT8+ T cells in the T-TA AMLR does not result in a further increase in the suppressor activity of OKT8+ T cells. In summary, in the T-non-T and T-TA AMLR phenotypically similar T-cell subpopulations proliferate but express distinct immunoregulatory functions and perhaps regulate the tempo of the AMLR.
在本研究中，我们已经证明，在T-TA自体混合淋巴细胞反应（AMLR）中，OKT4+ T细胞是主要的反应细胞；然而，在有额外白细胞介素-2（IL-2）存在的情况下，OKT8+ T细胞也会通过增殖作出反应。在T-非T AMLR中被激活的OKT4+和OKT8+ T细胞，在T-TA AMLR中都作为刺激细胞起作用。在T-TA AMLR中被激活的OKT4+ T细胞会抑制新鲜T-非T AMLR的增殖反应；对照OKT4+细胞在该系统中未显示出免疫调节活性。相比之下，对照OKT8+ T细胞会自发抑制T-非T AMLR的增殖，但在T-TA AMLR中激活OKT8+ T细胞并不会导致OKT8+ T细胞的抑制活性进一步增强。总之，在T-非T和T-TA AMLR中，表型相似的T细胞亚群会增殖，但表达不同的免疫调节功能，并且可能调节AMLR的进程。
