Rosenberg D R, Sweeney J A, Gillen J S, Kim J, Varanelli M J, O'Hearn K M, Erb P A, Davis D, Thulborn K R
Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA.
J Am Acad Child Adolesc Psychiatry. 1997 Jun;36(6):853-9. doi: 10.1097/00004583-199706000-00024.
It was hypothesized that a scanner simulator that replicates the magnetic resonance imaging (MRI) environment could be used to prepare pediatric subjects for successful completion of a diagnostic-quality MRI examination without pharmacological sedation.
Sixteen healthy children, 6 to 17 years of age, were matched for age and sex with 16 psychotropic medication-naive children with obsessive-compulsive disorder. Distress was measured throughout simulation and scanning procedures using heart rate and a self-report distress scale. Ten healthy children, 6 to 17 years of age, also underwent the same actual MRI scanning procedure but did not undergo the simulation scanning procedure.
Significant decreases in heart rate and self-reported distress level were observed in all subjects during the simulator session that were maintained to the end of the actual scanner experience. All subjects successfully completed MRI examinations without chemical restraint. Subjects who were not trained in the simulator had higher heart rates and self-reported distress levels in the actual scanner than did simulation-trained subjects.
Simulation without pharmacological sedation successfully prepared pediatric subjects in this pilot study for high-quality MRI studies. Subject preparation may be an alternative procedure to sedation for routine MRI examination in healthy and anxious children 6 years of age and older.
据推测,一种能够复制磁共振成像(MRI)环境的扫描仪模拟器可用于让儿科受试者做好准备,从而在无需药物镇静的情况下成功完成诊断级别的MRI检查。
16名6至17岁的健康儿童,在年龄和性别上与16名未服用过精神药物的强迫症儿童相匹配。在整个模拟和扫描过程中,使用心率和自我报告的痛苦量表来测量痛苦程度。10名6至17岁的健康儿童也接受了相同的实际MRI扫描程序,但未进行模拟扫描程序。
在模拟器环节中,所有受试者的心率和自我报告的痛苦程度均显著降低,且这种降低一直持续到实际扫描仪体验结束。所有受试者均在无化学约束的情况下成功完成了MRI检查。未接受模拟器训练的受试者在实际扫描仪中的心率和自我报告的痛苦程度高于接受模拟训练的受试者。
在这项初步研究中,无药物镇静的模拟成功让儿科受试者为高质量的MRI研究做好了准备。对于6岁及以上健康和焦虑儿童的常规MRI检查,受试者准备可能是一种替代镇静的方法。