Labesse G, Colloc'h N, Pothier J, Mornon J P
Système Moléculaire et Biologie Structurale, Universités Paris 6/Paris 7, CNRS URA 09, France.
Comput Appl Biosci. 1997 Jun;13(3):291-5. doi: 10.1093/bioinformatics/13.3.291.
The secondary structure is a key element of architectural organization in proteins. Accurate assignment of the secondary structure elements (SSE) (helix, strand, coil) is an essential step for the analysis and modelling of protein structure. Various methods have been proposed to assign secondary structure. Comparative studies of their results have shown some of their drawbacks, pointing out the difficulties in the task of SSE assignment.
We have designed a new automatic method, named P-SEA, to assign efficiently secondary structure from the sole C alpha position. Some advantages of the new algorithm are discussed.
The program P-SEA is available by anonymous ftp: ftp.lmcp.jussieu.fr directory: pub/.
二级结构是蛋白质结构组织的关键要素。准确分配二级结构元件（SSE）（螺旋、链、卷曲）是蛋白质结构分析和建模的重要步骤。已经提出了各种方法来分配二级结构。对其结果的比较研究显示了它们的一些缺点，指出了SSE分配任务中的困难。
我们设计了一种名为P-SEA的新自动方法，可从唯一的Cα位置高效分配二级结构。讨论了新算法的一些优点。
程序P-SEA可通过匿名ftp获得：ftp.lmcp.jussieu.fr目录：pub/。
