Klaus A M, Schlingloff Y, Kleinitz U, Böttcher M, Hapke H J
Institut für Pharmakologie, Toxikologie und Pharmazie, Tierärztliche Hochschule Hannover, Germany.
J Vet Pharmacol Ther. 1997 Jun;20(3):204-8. doi: 10.1111/j.1365-2885.1997.tb00096.x.
The pharmacokinetic behaviour of dipyrone metabolite 4-MAA in serum was determined in seven horses of different breeds after a single intravenous dose administration. A biexponential formula was fitted to the serum concentration vs. time data. The median half-life of the elimination phase (t1/2 beta) was 4.85 h (range 5.04 h), the median volume of distribution (Vd(area)) was 1.85 L/kg (range 3.2 L/kg) and median of total clearance was 4.0 mL/min/kg (range 2.3 mL/min/kg).
在7匹不同品种的马静脉注射单剂量安乃近代谢物4-甲氨基安替比林后，测定了其在血清中的药代动力学行为。用双指数公式拟合血清浓度与时间的数据。消除相的中位半衰期（t1/2β）为4.85小时（范围5.04小时），中位分布容积（Vd(area)）为1.85升/千克（范围3.2升/千克），总清除率的中位数为4.0毫升/分钟/千克（范围2.3毫升/分钟/千克）。
