McNab A A
Department of Ophthalmology, Royal Melbourne Hospital, Australia.
Ophthalmic Plast Reconstr Surg. 1997 Jun;13(2):98-114. doi: 10.1097/00002341-199706000-00005.
Floppy eyelid syndrome (FES) usually affects middle-aged obese men, presenting as a unilateral or bilateral chronic papillary conjunctivitis. The upper eyelid is lax, floppy, and easily everted. The laterality corresponds to the side the patient sleeps on. An association with obstructive sleep apnea (OSA) has been suggested. A personal series of 17 new cases is presented, and 79 previously reported cases are reviewed to give a detailed description of the syndrome. In addition to the classical presentation, patients may present with upper lid ptosis, lash ptosis or trichiasis, lower lid ectropion or rarely entropion, or corneal complications. Eight patients with FES were investigated for OSA. Twenty other patients with known OSA were examined for FES and other possibly associated ocular features. All eight patients referred for sleep studies were found to have OSA. One of the 20 patients with known OSA was found to have FES, and two had features of early asymptomatic FES. One patient with FES and OSA had normal tension glaucoma. Patients with FES should be considered for sleep studies because of the known morbidity of OSA. Simple screening of patients with OSA may detect FES and avoid late corneal complications that can compromise vision.
睑皮松弛综合征（FES）通常影响中年肥胖男性，表现为单侧或双侧慢性乳头性结膜炎。上睑松弛、下垂，且容易翻转。病变侧与患者睡眠时所朝的一侧一致。有人提出该综合征与阻塞性睡眠呼吸暂停（OSA）有关。本文报告了17例新病例，并回顾了79例既往报道的病例，以详细描述该综合征。除了典型表现外，患者还可能出现上睑下垂、睫毛下垂或倒睫、下睑外翻或罕见的内翻，或角膜并发症。对8例FES患者进行了OSA检查。对另外20例已知患有OSA的患者进行了FES及其他可能相关眼部特征的检查。所有8例转诊进行睡眠研究的患者均被发现患有OSA。在20例已知患有OSA的患者中，1例被发现患有FES，2例有早期无症状FES的特征。1例患有FES和OSA的患者患有正常眼压性青光眼。鉴于已知OSA的发病率，FES患者应考虑进行睡眠研究。对OSA患者进行简单筛查可能会发现FES，并避免可能损害视力的晚期角膜并发症。
