Quraishy M S, Chescoe D, Mullervy J, Coates M, Hinton R H, Bailey M E
Department of Surgery, Royal Surrey County Hospital, Guildford, UK.
HPB Surg. 1996;10(1):11-20. doi: 10.1155/1996/43159.
Increased amounts of intestinal endotoxin are absorbed in obstructive jaundice. The precise mechanism is not known but the increased absorption may arise from alterations in the luminal contents, in the intestinal flora, in the gut wall or in interactions between all three. To examine the effects of the intestinal flora we have compared the morphological changes in the small intestine in obstructive jaundice in germ free and conventional rats while the effects of bile constituents have been examined by addition of bile constituents to the diet of bile duct ligated rats. Changes in the intestine were examined, histologically, by enzyme histochemistry, and by transmission and scanning electron microscopy. The results showed no differences in response between germ free and conventional rats. Feeding of diets containing bile salts exacerbated the lesion. Feeding of diets containing cholesterol, however, reduced the degree of intestinal changes produced by cholestasis and completely antagonised the increase in damage caused by feeding of bile salts.
在梗阻性黄疸中，肠道内毒素的吸收量会增加。确切机制尚不清楚，但吸收增加可能源于管腔内容物、肠道菌群、肠壁或三者之间相互作用的改变。为了研究肠道菌群的影响，我们比较了无菌大鼠和普通大鼠在梗阻性黄疸时小肠的形态变化，同时通过在胆管结扎大鼠的饮食中添加胆汁成分来研究胆汁成分的影响。通过酶组织化学、透射电子显微镜和扫描电子显微镜从组织学角度检查肠道的变化。结果显示无菌大鼠和普通大鼠的反应没有差异。喂食含胆汁盐的饮食会加重病变。然而，喂食含胆固醇的饮食可减轻胆汁淤积引起的肠道变化程度，并完全对抗喂食胆汁盐所导致的损伤增加。
