Martin C, Enbom M, Söderström M, Fredrikson S, Dahl H, Lycke J, Bergström T, Linde A
Department of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden.
Acta Neurol Scand. 1997 May;95(5):280-3. doi: 10.1111/j.1600-0404.1997.tb00210.x.
Several members of the herpesvirus family have been implicated in the pathogenesis of multiple sclerosis (MS). Recently, HHV-6 viral antigen has been demonstrated in association to MS plaques, as well as DNA from human herpesvirus 6 (HHV-6) in cerebrospinal fluid from a few MS patients by polymerase chain reaction (PCR). In the present study, CSF from patients with MS, optic neuritis and other neurological diseases, as well as consecutive CSF and serum samples from MS patients included in a clinical trial with acyclovir, were analysed by nested PCR for the presence of DNA from herpes simplex virus 1 and 2, Epstein-Barr virus, varicella zoster virus, cytomegalovirus, human herpesvirus 6 and 7. No virus DNA was found in any CSF (n = 115) or serum (n = 116) sample. These findings argue against a continuous disseminated herpesvirus infection in MS, but do not rule out a lesion-associated, low-grade herpesvirus infection within the MS brain.
疱疹病毒家族的几个成员已被认为与多发性硬化症（MS）的发病机制有关。最近，通过聚合酶链反应（PCR）在少数MS患者的脑脊液中发现了与MS斑块相关的HHV-6病毒抗原以及人类疱疹病毒6型（HHV-6）的DNA 。在本研究中，对MS、视神经炎和其他神经系统疾病患者的脑脊液，以及参加阿昔洛韦临床试验的MS患者连续的脑脊液和血清样本，采用巢式PCR分析单纯疱疹病毒1型和2型、爱泼斯坦-巴尔病毒、水痘带状疱疹病毒、巨细胞病毒、人类疱疹病毒6型和7型的DNA 。在任何脑脊液样本（n = 115）或血清样本（n = 116）中均未发现病毒DNA 这些发现不支持MS中存在持续性播散性疱疹病毒感染，但不排除MS脑内存在与病变相关的低度疱疹病毒感染。
