Herzberg U, Eliav E, Dorsey J M, Gracely R H, Kopin I J
Clinical Neuroscience Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA.
Neuroreport. 1997 May 6;8(7):1613-8. doi: 10.1097/00001756-199705060-00012.
Chronic constriction injury (CCI) of the rat sciatic nerve, which within 3 days induces thermal and mechanical hyperalgesia and mechanical allodynia, is used as a model for pain resulting from nerve injury. Involvement of nerve growth factor (NGF) in the development of this hyperalgesia is suggested by the increase in the level of mRNA encoding NGF in cells in the injured area and in dorsal root ganglia at the level of the lesion and the greatly increased NGF levels (determined by ELISA) in the ganglia ipsilateral to the CCI. Application of anti-serum to NGF at the site of CCI delayed the appearance of hyperalgesia, whereas pre-immune serum appeared to enhance it. These results are consistent with the view that NGF is an important factor in the appearance of hyperalgesia associated with unilateral mononeuropathy.
大鼠坐骨神经慢性压迫性损伤（CCI）在3天内会诱发热痛觉过敏、机械性痛觉过敏和机械性异常性疼痛，该损伤被用作神经损伤所致疼痛的模型。损伤区域的细胞以及损伤水平处背根神经节中编码神经生长因子（NGF）的mRNA水平升高，且CCI同侧神经节中NGF水平（通过ELISA测定）大幅增加，这表明NGF参与了这种痛觉过敏的发展。在CCI部位应用抗NGF血清可延迟痛觉过敏的出现，而免疫前血清似乎会增强痛觉过敏。这些结果与以下观点一致，即NGF是与单侧单神经病相关的痛觉过敏出现的重要因素。
