Tulasne J J, Litamoi J K, Morein B, Dedieu L, Palya V J, Yami M, Abusugra I, Sylla D, Bensaid A
Centre de Coopération Internationale en Recherche Agronomique et pour le Développment-Département d'Elevage et de Médecine Vétérinaire (CIRAD-EMVT), Montpellier, France.
Rev Sci Tech. 1996 Dec;15(4):1373-96. doi: 10.20506/rst.15.4.991.
The control of contagious bovine pleuropneumonia (CBPP) has been clearly identified by the Organisation of African Unity/Inter-African Bureau of Animal Resources as a priority. In the first part of this article, the authors introduce the past and present vaccines, based on the two classic strains, T1, and KH3J. They describe the guidelines for vaccine production technology, and the quality control requirements for CBPP vaccines of the Office International des Epizooties. The failure of the currently used T1-SR vaccine to provoke satisfactory immunity in cattle, particularly in the newly infected areas of Africa, is pointed out. Other shortcomings of the current CBPP vaccines are also highlighted. Thus, there is a need to improve CBPP vaccines and the authors propose detailed emergency measures to address this problem. In the second part of the article, a subunit approach using immunostimulating complex technology is outlined. The authors emphasise the importance of current research in cell-mediated immunity and immunopathology, which is aimed at improving the efficacy of CBPP vaccines.
非洲统一组织/非洲动物资源局已明确将牛传染性胸膜肺炎（CBPP）的防控列为优先事项。在本文的第一部分，作者介绍了基于两种经典毒株T1和KH3J的过去和现在的疫苗。他们描述了疫苗生产技术指南以及国际兽疫局对CBPP疫苗的质量控制要求。指出了目前使用的T1-SR疫苗在牛群中未能引发令人满意的免疫力，尤其是在非洲新感染地区。还强调了当前CBPP疫苗的其他缺点。因此，有必要改进CBPP疫苗，作者提出了详细的应急措施来解决这一问题。在本文的第二部分，概述了使用免疫刺激复合物技术的亚单位方法。作者强调了当前在细胞介导免疫和免疫病理学方面的研究的重要性，这些研究旨在提高CBPP疫苗的效力。
