Mori F, Ishiko S, Abiko T, Kitaya N, Kato Y, Kanno H, Yoshida A
Department of Ophthalmology, Asahikawa Medical College, Japan.
Curr Eye Res. 1997 Jun;16(6):534-8. doi: 10.1076/ceyr.16.6.534.5079.
We investigated corneal and lens autofluorescence in patients with proliferative diabetic retinopathy (PDR) to determine a correlation between the two parameters and blood glucose levels and HbA1c.
Corneal and lens autofluorescence levels in 17 PDR patients and 8 healthy controls were measured with a fluorophotometer fitted with an anterior segment adapter. We measured the lower blood glucose level (BS1), corneal autofluorescence (CA1), and lens autofluorescence (LA1) simultaneously and the higher blood glucose level (BS2), CA2, and LA2 simultaneously on the same day. We defined parameter changes as: delta BS = BS2 - BS1, delta CA = CA2 - CA1, and delta LA = LA2 - LA1.
Corneal and lens autofluorescence significantly increased in the patients, compared with the controls (p < 0.001). Lens autofluorescence had a significant positive correlation with HbA1c (r = 0.656, p < 0.01) in the patients. delta CA (ngEq/ml) correlated significantly with delta BS (mg/dl) (r = 0.631, P < 0.01).
Results suggest that lens autofluorescence might represent the long-term control of diabetes, and corneal autofluorescence levels may represent short-term changes in the blood glucose level, because hyperglycemia accelerates with increasing corneal autofluorescence in PDR patients. Corneal and lens autofluorescence may be related to the breakdown of the blood-aqueous barrier.
我们研究了增殖性糖尿病视网膜病变（PDR）患者的角膜和晶状体自发荧光，以确定这两个参数与血糖水平和糖化血红蛋白（HbA1c）之间的相关性。
使用配备前段适配器的荧光光度计测量了17例PDR患者和8名健康对照者的角膜和晶状体自发荧光水平。我们在同一天同时测量了较低血糖水平（BS1）、角膜自发荧光（CA1）和晶状体自发荧光（LA1），以及较高血糖水平（BS2）、CA2和LA2。我们将参数变化定义为：ΔBS = BS2 - BS1，ΔCA = CA2 - CA1，以及ΔLA = LA2 - LA1。
与对照组相比，患者的角膜和晶状体自发荧光显著增加（p < 0.001）。患者中，晶状体自发荧光与HbA1c呈显著正相关（r = 0.656，p < 0.01）。ΔCA（ngEq/ml）与ΔBS（mg/dl）显著相关（r = 0.631，P < 0.01）。
结果表明，晶状体自发荧光可能代表糖尿病的长期控制情况，而角膜自发荧光水平可能代表血糖水平的短期变化，因为在PDR患者中，高血糖会随着角膜自发荧光的增加而加速。角膜和晶状体自发荧光可能与血-房水屏障的破坏有关。
