Fama R, Sullivan E V, Shear P K, Marsh L, Yesavage J A, Tinklenberg J R, Lim K O, Pfefferbaum A
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Calif, USA.
Arch Neurol. 1997 Jun;54(6):719-28. doi: 10.1001/archneur.1997.00550180039010.
To examine whether each of the 5 Mattis Dementia Rating Scale (DRS) scores related to magnetic resonance imaging-derived volumes of specific cortical or limbic brain regions in patients with Alzheimer disease (AD).
Relations between DRS measures and regional brain volume measures were tested with bivariate and multivariate regression analyses.
The Aging Clinical Research Center of the Stanford (Calif) University Department of Psychiatry and Behavioral Science and the Geriatric Psychiatry Rehabilitation Unit of the Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif.
Fifty patients with possible or probable AD. Magnetic resonance imaging data from 136 healthy control participants, age 20 to 84 years, were used to correct brain volumes for normal variation arising from intracranial volume and age.
The DRS scores and volumes of regional cortical gray matter and of the hippocampus.
Memory scores of the patients with AD were selectively related to hippocampal volumes. Attention and construction scores were related to several anterior brain volume measures, with attention showing a significantly greater association to right than left hemisphere measures. Initiation/perseveration scores were not significantly correlated with any measure of regional gray matter volume, but performance was related to prefrontal sulcal widening, with a greater association with the left than right sulcal volume.
Certain DRS subtests are predictably correlated with selective regional brain volumes in AD. The specific relation between memory and hippocampal volumes and the nonsignificant relations between memory and regional cortical volumes suggest a dissociation between cortical and hippocampal contributions to explicit memory performance.
研究阿尔茨海默病（AD）患者的5项马蒂斯痴呆评定量表（DRS）得分是否与磁共振成像得出的特定皮质或边缘脑区体积相关。
采用双变量和多变量回归分析测试DRS测量值与脑区体积测量值之间的关系。
加利福尼亚州斯坦福大学精神病学与行为科学系衰老临床研究中心以及加利福尼亚州帕洛阿尔托退伍军人事务部帕洛阿尔托医疗保健系统老年精神病康复科。
50例可能或确诊为AD的患者。使用来自136名年龄在20至84岁之间的健康对照参与者的磁共振成像数据，对脑体积因颅内体积和年龄引起的正常变化进行校正。
DRS得分以及区域皮质灰质和海马体的体积。
AD患者的记忆得分与海马体体积选择性相关。注意力和构图得分与多个前脑体积测量值相关，注意力与右侧半球测量值的关联显著大于左侧。启动/持续得分与区域灰质体积的任何测量值均无显著相关性，但表现与前额沟增宽有关，与左侧沟体积的关联大于右侧。
在AD中，某些DRS子测试可预测地与选择性区域脑体积相关。记忆与海马体体积之间的特定关系以及记忆与区域皮质体积之间的无显著关系表明，皮质和海马体对显性记忆表现的贡献存在分离。
