整合起来：通过受体结构域的缔合实现G蛋白偶联受体中的信号转导
Getting it together: signal transduction in G-protein coupled receptors by association of receptor domains.
作者信息
Underwood D J, Prendergast K
机构信息
Merck Research Laboratories, West Point, PA 19486, USA.
出版信息
Chem Biol. 1997 Apr;4(4):239-48. doi: 10.1016/s1074-5521(97)90067-3.
PMID:9195871
Abstract
The mechanism of signal transduction by G-protein coupled receptors is unknown. Here, we propose that these receptors signal in a way that is qualitatively similar to that seen in the chemokine and endocrine hormone receptor families; the signal occurs when two domains of the receptor are brought together, although this is not the only requirement for signaling.
摘要
G蛋白偶联受体的信号转导机制尚不清楚。在此，我们提出这些受体的信号传导方式在性质上类似于趋化因子和内分泌激素受体家族中所观察到的方式；当受体的两个结构域聚集在一起时信号就会出现，尽管这并非信号传导的唯一条件。
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