一种与神经调节蛋白相关的基因Don-1的特性，该基因在小脑和海马体的特定区域高度表达。
Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus.
作者信息
Busfield S J, Michnick D A, Chickering T W, Revett T L, Ma J, Woolf E A, Comrack C A, Dussault B J, Woolf J, Goodearl A D, Gearing D P
机构信息
Millennium Pharmaceuticals Incorporated, Cambridge, Massachusetts 02139, USA.
出版信息
Mol Cell Biol. 1997 Jul;17(7):4007-14. doi: 10.1128/MCB.17.7.4007.
Abstract
Members of the epidermal growth factor family of receptors have long been implicated in the pathogenesis of various tumors, and more recently, apparent roles in the developing heart and nervous system have been described. Numerous ligands that activate these receptors have been isolated. We report here on the cloning and initial characterization of a second ligand for the erbB family of receptors. This factor, which we have termed Don-1 (divergent of neuregulin 1), has structural similarity with the neuregulins. We have isolated four splice variants, two each from human and mouse, and have shown that they are capable of inducing tyrosine phosphorylation of erbB3, erbB4, and erbB2. In contrast to those of neuregulin, high levels of expression of Don-1 are restricted to the cerebellum and dentate gyrus in the adult brain and to fetal tissues.
摘要
表皮生长因子受体家族成员长期以来一直被认为与各种肿瘤的发病机制有关，最近，在发育中的心脏和神经系统中也发现了其明显作用。许多激活这些受体的配体已被分离出来。我们在此报告erbB受体家族第二种配体的克隆及初步特性。这个因子，我们称之为Don-1（神经调节蛋白1的变体），与神经调节蛋白具有结构相似性。我们分离出了四种剪接变体，人源和鼠源各两种，并已证明它们能够诱导erbB3、erbB4和erbB2的酪氨酸磷酸化。与神经调节蛋白不同，Don-1在成人大脑中的高表达仅限于小脑和齿状回以及胎儿组织。
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