van Weissenbruch R, Albers F W, Bouckaert S, Nelis H J, Criel G, Remon J P, Sulter A M
Department of Otorhinolaryngology, University Hospital Groningen, The Netherlands.
Acta Otolaryngol. 1997 May;117(3):452-8. doi: 10.3109/00016489709113420.
Device life of tracheoesophageal voice prostheses is limited due to deterioration of the polymers. A group of 55 postlaryngectomy patients fitted with a Provox voice prosthesis have been studied prospectively during 6 months. Thirty-seven prostheses were replaced due to a dysfunctional valve mechanism. Although colonization with Candida species was highly associated with destruction of the silicone material, other upper respiratory tract commensals, e.g. Staphylococcus aureus, were also demonstrated. Electron microscopy of the contaminated devices showed colonization and disruption of the silicone material by penetrating yeast hyphae. During the study a remarkable increase of intratracheal phonatory pressures was assessed with progressive colonization of the prostheses.
由于聚合物的降解，气管食管语音假体的使用寿命有限。一组55例喉切除术后佩戴Provox语音假体的患者进行了为期6个月的前瞻性研究。37个假体因瓣膜机制功能障碍而被更换。尽管念珠菌属的定植与硅酮材料的破坏高度相关，但也发现了其他上呼吸道共生菌，如金黄色葡萄球菌。对受污染装置的电子显微镜检查显示，穿透性酵母菌丝使硅酮材料发生定植和破坏。在研究过程中，随着假体定植的进展，气管内发声压力显著增加。
