Walton N H, Bowden S C
Department of Psychology, University of Melbourne, Parkville, Victoria, Australia.
Alcohol Alcohol. 1997 May-Jun;32(3):287-95. doi: 10.1093/oxfordjournals.alcalc.a008269.
In the search for explanation of persistent cognitive impairment associated with alcohol dependence, the possible role of liver disease has aroused considerable interest. However, review of the relevant literature provides only ambiguous support for any general relationship between neuropsychological status and laboratory tests of liver function. We tested the general hypothesis, and also two specific hypotheses relating particular liver function parameters (gamma-glutamyl transferase and serum albumin) to mental ability in a sample of 54 recently detoxified alcohol-dependent people. Despite adequate design power, we failed to obtain evidence for general or specific correlations between mental ability and liver function. We conclude that the accumulated data do not provide direct support for the hypothesis that liver disease plays a part in the genesis of chronic alcohol-related brain impairment in clients without cirrhosis.
在探寻与酒精依赖相关的持续性认知障碍的解释过程中，肝脏疾病的可能作用引发了相当大的关注。然而，对相关文献的回顾仅为神经心理状态与肝功能实验室检查之间的任何一般关系提供了模糊的支持。我们在54名近期戒酒的酒精依赖者样本中检验了一般假设，以及另外两个将特定肝功能参数（γ-谷氨酰转移酶和血清白蛋白）与心理能力相关联的特定假设。尽管设计能力充足，但我们未能获得心理能力与肝功能之间存在一般或特定相关性的证据。我们得出结论，现有数据并未直接支持肝脏疾病在无肝硬化的患者慢性酒精相关脑损伤发生中起作用这一假设。
