Nakanishi Y, Chen S, Inutsuka S, Ma Y, Jiang X, Hara N, Sera N, Tokiwa H
Research Institute for Diseases of the Chest, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Neoplasma. 1997;44(1):69-72.
Fuyuan Country, in Yunnan Province, China has an extremely high lung cancer mortality both in males and non-smoking females. Out of 5768 deaths, 588 patients died of malignant diseases. Lung cancer was the number one cause of death among malignant diseases both in males and females. The rate of lung cancer death to the whole of malignant diseases was 56.2% for males and 55.0% for females. Indoor soot and combustion emission derived from smoky coal produced in northern Fuyuan exhibited high mutagenic activities against Salmonella typhimurium TA98 strain in Ames test. Resected lung tissues derived from the patients with lung cancer in Fuyuan contained significantly higher concentrations of benzo(a)pyrene than those in Japan, both in males and females (i.e., 608.7 +/- 477.1 pg/dry weight for samples of the patients in Fuyuan, 180.1 +/- 104.5 for Japanese non-smokers, and 207.5 +/- 98.8 for Japanese heavy smokers, respectively). These results suggest that mutagenic chemicals contained in coal as well as indoor environment may have a great influence on lung carcinogenesis in Fuyuan, Yunnan Province, China.
中国云南省富源县的肺癌死亡率在男性和不吸烟女性中都极高。在5768例死亡病例中，588例患者死于恶性疾病。肺癌是男性和女性恶性疾病中的首要死因。男性肺癌死亡占全部恶性疾病死亡的比例为56.2%，女性为55.0%。富源县北部产的烟煤产生的室内烟尘和燃烧排放物在艾姆斯试验中对鼠伤寒沙门氏菌TA98菌株表现出高诱变活性。富源县肺癌患者的切除肺组织中苯并(a)芘的浓度显著高于日本，男性和女性均如此（即富源县患者样本为608.7±477.1 pg/干重，日本不吸烟者为180.1±104.5，日本重度吸烟者为207.5±98.8）。这些结果表明，煤以及室内环境中含有的诱变化学物质可能对中国云南省富源县的肺癌发生有很大影响。
