Holstein B
Acta Physiol Scand. 1977 Oct;101(2):185-93. doi: 10.1111/j.1748-1716.1977.tb05997.x.
Gastric acid secretion was measured in swimming codfish surgically equipped with a catheter draining the stomach. Gastric acid secretion was stimulated by histamine (5 or 15 microgram/kg-h) or by carbachol (5 microgram/kg-h). Pretreatment with atropine (1 mumol/kg-h) completely prevented the acid secretion induced by carbachol, but did not influence the secretion induced by histamine. Atropine had marked effects on the motor functions of the stomach, and seriously reduced the volume draining from the stomach. Infusion of phenol red indicated that the decrease in volume was due to a decrease in recovery of ingested water. SC-15396, "antigastrin", significantly depressed acid secretion induced by histamine, and reduced carbachol-stimulated secretion, although the later was statistically insignificant. The effects of SC-15396 is discussed with reference to the absence of receptors for gastrin related to gastric acid secretion in the codfish stomach.
对通过手术安装了用于引流胃内容物导管的游动鳕鱼测量胃酸分泌。组胺（5或15微克/千克·小时）或卡巴胆碱（5微克/千克·小时）可刺激胃酸分泌。用阿托品（1微摩尔/千克·小时）预处理可完全阻止卡巴胆碱诱导的胃酸分泌，但不影响组胺诱导的分泌。阿托品对胃的运动功能有显著影响，并严重减少从胃中引流的体积。酚红输注表明体积减少是由于摄入水分恢复减少所致。“抗胃泌素”SC - 15396显著抑制组胺诱导的胃酸分泌，并减少卡巴胆碱刺激的分泌，尽管后者在统计学上不显著。结合鳕鱼胃中不存在与胃酸分泌相关的胃泌素受体来讨论SC - 15396的作用。
