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H2受体拮抗剂甲硫米特对大西洋鳕鱼（Gadus morhua）中卡巴胆碱和组胺诱导的胃酸分泌的影响。

Effect of the H2-receptor antagonist metiamide on carbachol- and histamine-induced gastric acid secretion in the Atlantic cod,Gadus morhua.

作者信息

Holstein B

出版信息

Acta Physiol Scand. 1976 Jun;97(2):189-95. doi: 10.1111/j.1748-1716.1976.tb10251.x.

DOI:10.1111/j.1748-1716.1976.tb10251.x
PMID:949004
Abstract

Gastric acid secretion was measured in swimming codfish surgically equipped with a catheter draining the stomach. Intramuscular injection of histamine (15.6 mug/kg-h) or carbachol (5 mug/kg-h) stimulated the secretion of acid, carbachol in addition caused a marked decrease in drinking rate of the fishes. Administration of 10 mumol/kg-h metiamide completely prevented the acid secretion induced by both drugs. The carbachol effect on the drinking rate, interpreted to mirror contraction of the stomach following stimulation of muscarinic receptors, was not affected by metiamide.

摘要

通过手术安装导管引流胃内容物的方式，对游动的鳕鱼进行胃酸分泌测定。肌肉注射组胺（15.6微克/千克·小时）或卡巴胆碱（5微克/千克·小时）可刺激胃酸分泌，此外，卡巴胆碱还会导致鱼的饮水速率显著降低。给予10微摩尔/千克·小时的甲硫咪胺可完全抑制两种药物诱导的胃酸分泌。卡巴胆碱对饮水速率的影响（被解释为毒蕈碱受体受刺激后胃收缩的反映）不受甲硫咪胺的影响。

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