Vieregge P, Stolze H, Klein C, Heberlein I
Department of Neurology, Medical University of Lübeck, Federal Republic of Germany.
J Neural Transm (Vienna). 1997;104(2-3):237-48. doi: 10.1007/BF01273184.
Stride parameters were established in 17 patients with idiopathic Parkinson's disease (PD; mean age 68.8 yrs.; Hoehn-Yahr stages 2 and 3) and in 33 healthy age-matched controls. Free-walking speed was lower in PD as were stride length and cadence. Impaired locomotor synergies in PD were reflected by a higher coefficient of variation of stride length; step width and its coefficient of variation (the latter related to postural imbalance in locomotion) were not changed. No stride parameter correlated with any total score of either the Hoehn-Yahr Scale, the Unified Parkinson's Disease Rating Scale Motor Examination ("UPDRS-III"), the Columbia Rating Scale (CURS) or the Webster Rating Scale. Stride length correlated with a CURS-Bradykinesia-Score, whereas gait velocity correlated with UPDRS-III-Axial-Motor-Score and with the CURS-Bradykinesia-Score. Hypokinesia of gait in moderately disabled PD patients is best assessed by combined analysis of stride parameters and locomotion-related subscores from conventional rating scales.
对17例特发性帕金森病（PD；平均年龄68.8岁；Hoehn-Yahr分期为2期和3期）患者及33名年龄匹配的健康对照者进行步幅参数测定。PD患者的自由行走速度、步幅长度和步频均较低。PD患者运动协同障碍表现为步幅长度变异系数较高；步宽及其变异系数（后者与运动时的姿势失衡有关）未发生改变。步幅参数与Hoehn-Yahr量表、统一帕金森病评定量表运动检查（“UPDRS-III”）、哥伦比亚评定量表（CURS）或韦伯斯特评定量表的任何总分均无相关性。步幅长度与CURS-运动迟缓评分相关，而步态速度与UPDRS-III-轴向运动评分及CURS-运动迟缓评分相关。对于中度残疾的PD患者，步态运动不能最好通过步幅参数与传统评定量表中运动相关子评分的联合分析来评估。
