人类巨噬细胞分化的两条不同途径由干扰素-γ和白细胞介素-10介导。
Two distinct pathways of human macrophage differentiation are mediated by interferon-gamma and interleukin-10.
作者信息
Orlikowsky T, Wang Z Q, Dudhane A, Horowitz H, Conti B, Hoffmann M K
机构信息
New York Medical College, Department of Microbiology, Valhalla 10595, USA.
出版信息
Immunology. 1997 May;91(1):104-8. doi: 10.1046/j.1365-2567.1997.00204.x.
Abstract
Forming cellular conjugates with T cells, macrophages can help their targets to mount an immune response or they can destroy the targeted T cell. The two functions are performed by two distinct macrophage subsets that can be distinguished by cell surface marker phenotypes, B7+ CD16- and B7- CD16+. Interferon-gamma (IFN-gamma) induces the former, interleukin-10 (IL-10) induces the latter phenotype. The two macrophage differentiation pathways are mutually exclusive; each cytokine inhibits the effect of the other cytokine. The second messenger cAMP enhances the macrophage B7 expression and suppresses the macrophage CD16 expression. However, together with IL-10, cAMP blocks the generation of both macrophage phenotypes. In the chimpanzee we noted deviations from this differentiation pattern that are suggestive of an enhanced IL-10 presence in the primate environment.
摘要
巨噬细胞与T细胞形成细胞共轭体后，可帮助其靶标产生免疫反应，也可破坏被靶向的T细胞。这两种功能由两个不同的巨噬细胞亚群执行，可通过细胞表面标志物表型B7 + CD16 - 和B7 - CD16 + 进行区分。干扰素 - γ（IFN - γ）诱导前者，白细胞介素 - 10（IL - 10）诱导后者表型。这两条巨噬细胞分化途径相互排斥；每种细胞因子都会抑制另一种细胞因子的作用。第二信使cAMP增强巨噬细胞B7表达并抑制巨噬细胞CD16表达。然而，cAMP与IL - 10一起会阻断两种巨噬细胞表型的产生。在黑猩猩中，我们注意到这种分化模式存在偏差，这表明在灵长类动物环境中IL - 10的存在有所增强。
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本文引用的文献
1
AIDS patient monocytes target CD4 T cells for cellular conjugate formation and deletion through the membrane expression of HIV-1 envelope molecules.艾滋病患者单核细胞通过HIV-1包膜分子的膜表达靶向CD4 T细胞以形成细胞共轭体并使其缺失。
AIDS Res Hum Retroviruses. 1996 Jul 1;12(10):893-9. doi: 10.1089/aid.1996.12.893.
2
Monocytes in HIV type 1-infected individuals lose expression of costimulatory B7 molecules and acquire cytotoxic activity.
AIDS Res Hum Retroviruses. 1996 Jul 1;12(10):885-92. doi: 10.1089/aid.1996.12.885.
3
The role of the CD28 receptor during T cell responses to antigen.CD28受体在T细胞对抗原反应过程中的作用。
Annu Rev Immunol. 1993;11:191-212. doi: 10.1146/annurev.iy.11.040193.001203.
4
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Annu Rev Immunol. 1993;11:165-90. doi: 10.1146/annurev.iy.11.040193.001121.
5
Lack of T cell dysfunction and programmed cell death in human immunodeficiency virus type 1-infected chimpanzees correlates with absence of monocytotropic variants.1型人类免疫缺陷病毒感染的黑猩猩中缺乏T细胞功能障碍和程序性细胞死亡与缺乏嗜单核细胞变体相关。
J Infect Dis. 1993 Nov;168(5):1140-7. doi: 10.1093/infdis/168.5.1140.
6
Interference of interleukin-10 with human immunodeficiency virus type 1 replication in primary monocyte-derived macrophages.白细胞介素-10对人免疫缺陷病毒1型在原代单核细胞衍生巨噬细胞中复制的干扰作用。
J Virol. 1994 Nov;68(11):6967-75. doi: 10.1128/JVI.68.11.6967-6975.1994.
7
8
9
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AIDS Res Hum Retroviruses. 1994 Oct;10(10):1199-206. doi: 10.1089/aid.1994.10.1199.
10
IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression.白细胞介素-10通过选择性抑制B7表达的上调来抑制巨噬细胞共刺激活性。
J Immunol. 1993 Aug 1;151(3):1224-34.
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