博尔纳病
Borna disease.
作者信息
Hatalski C G, Lewis A J, Lipkin W I
机构信息
University of California, Irvine 92697-4290, USA.
出版信息
Emerg Infect Dis. 1997 Apr-Jun;3(2):129-35. doi: 10.3201/eid0302.970205.
Abstract
Borna disease virus, a newly classified nonsegmented negative-strand RNA virus with international distribution, infects a broad range of warm-blooded animals from birds to primates. Infection causes movement and behavioral disturbances reminiscent of some neuropsychiatric syndromes. The virus has not been clearly linked to any human disease; however, an association between infection with the virus and selected neuropsychiatric disorders has been suggested. We reviewed recent advances in Borna disease virus research, focusing on evidence of infection in humans.
摘要
博尔纳病病毒是一种新分类的不分节段的负链RNA病毒，在全球范围内均有分布，可感染从鸟类到灵长类动物等广泛的温血动物。感染会引发运动和行为障碍，使人联想到某些神经精神综合征。该病毒与任何人类疾病之间的联系尚不明确；然而，有人提出该病毒感染与特定神经精神疾病之间存在关联。我们回顾了博尔纳病病毒研究的最新进展，重点关注人类感染的证据。
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The atypical strategies used for gene expression of Borna disease virus, a nonsegmented, negative-strand RNA virus.博尔纳病病毒（一种不分节段的负链RNA病毒）基因表达所采用的非典型策略。
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Identification of host factors involved in borna disease virus cell entry through a small interfering RNA functional genetic screen.通过小干扰 RNA 功能遗传筛选鉴定参与博尔纳病病毒细胞进入的宿主因子。
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Cell entry of Borna disease virus follows a clathrin-mediated endocytosis pathway that requires Rab5 and microtubules.博尔纳病病毒的细胞进入遵循网格蛋白介导的内吞途径，该途径需要Rab5和微管。
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Borna disease virus requires cholesterol in both cellular membrane and viral envelope for efficient cell entry.博尔纳病病毒在细胞膜和病毒包膜中都需要胆固醇才能有效地进入细胞。
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Generation and characterization of a recombinant vesicular stomatitis virus expressing the glycoprotein of Borna disease virus.表达博尔纳病病毒糖蛋白的重组水疱性口炎病毒的产生及特性分析
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Cell-to-cell spread of Borna disease virus proceeds in the absence of the virus primary receptor and furin-mediated processing of the virus surface glycoprotein.博尔纳病病毒的细胞间传播在缺乏病毒主要受体以及病毒表面糖蛋白的弗林蛋白酶介导加工的情况下仍会发生。
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本文引用的文献
1
First isolates of infectious human Borna disease virus from patients with mood disorders.从情绪障碍患者中首次分离出传染性人类博尔纳病病毒。
Mol Psychiatry. 1996 Jul;1(3):200-12.
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Detection of Borna disease virus (BDV) antibodies and BDV RNA in psychiatric patients: evidence for high sequence conservation of human blood-derived BDV RNA.精神疾病患者中博尔纳病病毒（BDV）抗体和BDV RNA的检测：人血源性BDV RNA高度序列保守性的证据
J Virol. 1996 Nov;70(11):7713-24. doi: 10.1128/JVI.70.11.7713-7724.1996.
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Sequence characterization of human Borna disease virus.人类博尔纳病病毒的序列特征
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4
Detection of borna disease virus antigen and RNA in human autopsy brain samples from neuropsychiatric patients.在神经精神疾病患者的尸检脑样本中检测博尔纳病病毒抗原和RNA。
Virology. 1996 Sep 15;223(2):272-82. doi: 10.1006/viro.1996.0479.
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A neural substrate of hyperactivity in borna disease: changes in brain dopamine receptors.博尔纳病多动的神经基质：脑多巴胺受体的变化
Virology. 1996 Aug 15;222(2):332-8. doi: 10.1006/viro.1996.0430.
6
Borna disease virus and the consumption of raw horse meat.博尔纳病病毒与生马肉的食用
Nat Med. 1996 Sep;2(9):948-9. doi: 10.1038/nm0996-948b.
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Demonstration of borna disease virus RNA in peripheral blood mononuclear cells derived from domestic cats in Japan.日本家猫外周血单个核细胞中博尔纳病病毒RNA的检测
J Clin Microbiol. 1996 Jan;34(1):188-91. doi: 10.1128/jcm.34.1.188-191.1996.
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Developmental injury to the cerebellum following perinatal Borna disease virus infection.围产期博尔纳病病毒感染后小脑的发育性损伤。
Brain Res Dev Brain Res. 1995 Dec 21;90(1-2):45-53. doi: 10.1016/0165-3806(96)83485-7.
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Prevalence of Borna disease virus RNA in peripheral blood mononuclear cells from blood donors.献血者外周血单个核细胞中博尔纳病病毒RNA的流行率。
Med Microbiol Immunol. 1995 Oct;184(3):135-8. doi: 10.1007/BF00224350.
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Demonstration of Borna disease virus RNA in peripheral blood mononuclear cells derived from Japanese patients with chronic fatigue syndrome.
FEBS Lett. 1996 Jan 8;378(2):145-9. doi: 10.1016/0014-5793(95)01439-x.
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