Rübben A, Kalka K, Spelten B, Grussendorf-Conen E I
Department of Dermatology, University Hospital RWTH Aachen, Germany.
Arch Dermatol Res. 1997 May;289(6):337-40. doi: 10.1007/s004030050201.
The morphology of common warts depends on the inducing human papillomavirus (HPV) type. In order to assess the impact of the virus type on wart epidemiology we determined the virus type by PCR and recorded anamnestic data of 238 patients with common warts. Warts induced by the related HPV types 2, 27 and 57 predominated in the study population (n = 202). These warts mostly occurred as multiple verrucae vulgares, mosaic warts or endophytic warts. Patients aged between 10 and 30 years were most affected and they typically displayed a long disease history (mean duration of warts at the time of first clinical examination, 22 months). A different age distribution was observed in HPV 1-induced warts, most of which occurred in children 6-10 years of age. HPV 2-related warts responded only modestly to treatment, as they persisted in approximately 50% of all patients for more than 6 additional months. No sex preference was detected, but an association with atopic diseases was noted as 39.8% of patients with warts containing HPV 2-related viruses showed a history of atopic eczema, pollinosis or asthma as compared with 20.6% of the control population without a history of warts or with short-duration wart disease. Thus, our results indicate that the epidemiology, as well as morphology, of common warts is closely linked to the virus type.
寻常疣的形态取决于诱发的人乳头瘤病毒（HPV）类型。为了评估病毒类型对疣流行病学的影响，我们通过聚合酶链反应（PCR）确定了病毒类型，并记录了238例寻常疣患者的既往病史数据。在研究人群（n = 202）中，由相关HPV 2型、27型和57型诱发的疣最为常见。这些疣大多表现为多发性寻常疣、镶嵌疣或内生性疣。10至30岁的患者受影响最大，他们通常病程较长（首次临床检查时疣的平均持续时间为22个月）。在HPV 1型诱发的疣中观察到不同的年龄分布，其中大多数发生在6至10岁的儿童中。HPV 2型相关的疣对治疗反应一般，因为约50%的患者在额外6个月以上仍持续存在。未发现性别偏好，但注意到与特应性疾病有关联，因为在携带HPV 2型相关病毒的疣患者中，39.8%有特应性皮炎、花粉症或哮喘病史，而无疣病史或疣病程短的对照人群中这一比例为20.6%。因此，我们的结果表明，寻常疣的流行病学以及形态与病毒类型密切相关。
