Moberg P J, Doty R L, Turetsky B I, Arnold S E, Mahr R N, Gur R C, Bilker W, Gur R E
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA.
Am J Psychiatry. 1997 Jul;154(7):1016-8. doi: 10.1176/ajp.154.7.1016.
The authors examined the relationship between deficits in olfactory identification and duration of illness in young and elderly patients with schizophrenia.
Olfactory identification performance of 38 patients with schizophrenia and 40 normal subjects was compared by using the University of Pennsylvania Smell Identification Test.
The schizophrenic patients demonstrated olfactory deficits relative to the comparison group, and the elderly schizophrenic patients displayed a greater magnitude of olfactory deficit than the younger patients. Independent of normal aging effects and cognitive deficit, patients with schizophrenia showed a strong relationship between olfactory identification scores and duration of illness, which suggests that olfactory abilities decline progressively over the course of the disorder.
In contrast to other neuropsychological measures that have been reported to be stable over the course of illness, olfactory identification abilities deteriorate steadily in patients with schizophrenia, even for those with relatively recent onset.
作者研究了精神分裂症青年和老年患者嗅觉识别缺陷与病程之间的关系。
使用宾夕法尼亚大学嗅觉识别测试比较了38例精神分裂症患者和40名正常受试者的嗅觉识别表现。
与对照组相比，精神分裂症患者表现出嗅觉缺陷，老年精神分裂症患者的嗅觉缺陷程度比年轻患者更大。独立于正常衰老效应和认知缺陷，精神分裂症患者的嗅觉识别分数与病程之间存在密切关系，这表明嗅觉能力在疾病过程中逐渐下降。
与其他据报道在病程中保持稳定的神经心理学指标不同，精神分裂症患者的嗅觉识别能力即使对于那些起病相对较晚的患者也会持续恶化。
