Aldinger K A, Samaan N A
Ann Intern Med. 1977 Nov;87(5):571-3. doi: 10.7326/0003-4819-87-5-571.
Hypokalemia is a potentially life-threatening biochemical abnormality in patients with hypercalcemia. We studied a large group of patients with hypercalcemia to determine the prevalence of hypokalemia. One hundred three patients with normal renal function and no history of taking potassium-depleting drugs comprise the substance of this study. Thirty three of 103 patients (32%) were hypokalemic. A higher prevalence (52.3%) was found in patients with hypercalcemia associated with malignant disease than in those with primary hyperparathyroidism (16.9%). In addition, the degree and frequency of hypokalemia were greatest at the higher serum calcium levels. The presence of hypokalemia must be considered when treating severe hypercalcemia; otherwise, vigorous use of diuretics may result in profound hypokalemia and tachyrhythmias.
低血钾是高钙血症患者中一种潜在危及生命的生化异常。我们研究了一大群高钙血症患者以确定低血钾的患病率。本研究的主体为103例肾功能正常且无服用排钾药物史的患者。103例患者中有33例（32%）为低钾血症。与恶性疾病相关的高钙血症患者的低钾血症患病率（52.3%）高于原发性甲状旁腺功能亢进患者（16.9%）。此外，在血清钙水平较高时，低钾血症的程度和发生率最高。在治疗严重高钙血症时必须考虑低血钾的存在；否则，大量使用利尿剂可能导致严重低钾血症和快速心律失常。
