Burai L, Hietapelto V, Király R, Tóth E, Brücher E
Department of Inorganic and Analytical Chemistry, Lajos Kossuth University, Debrecen, Hungary.
Magn Reson Med. 1997 Jul;38(1):146-50. doi: 10.1002/mrm.1910380120.
Formation of ternary complexes between Gd-DTPA, Gd-DTPA-BMA, and Gd-DOTA, used as contrast enhancement agents in MRI and the endogenously available carbonate and phosphate ions, has been demonstrated. The extent of ternary complex formation and its effect on the proton relaxation, measured at 9 MHz, rates is negligible at around pH < 8. The complex Gd-EDTA forms more stable ternary complexes with carbonate and phosphate and it also strongly coordinates the terdentate citrate ligand. The formation of ternary complexes Gd-EDTA(X) (X = CO3(2-), Cit3-) results in a significant decrease in the proton relaxation rates under physiological conditions.
已证实，用作磁共振成像（MRI）造影剂的钆-二乙三胺五乙酸（Gd-DTPA）、钆-二乙三胺五乙酸双甲酰胺（Gd-DTPA-BMA）和钆-四氮杂环十二烷四乙酸（Gd-DOTA）与内源性可利用的碳酸根离子和磷酸根离子之间会形成三元复合物。在9兆赫下测量时，三元复合物的形成程度及其对质子弛豫速率的影响在pH值小于8左右时可忽略不计。钆-乙二胺四乙酸（Gd-EDTA）复合物与碳酸根和磷酸根形成更稳定的三元复合物，并且它还能强烈配位三齿柠檬酸配体。三元复合物钆-乙二胺四乙酸（X）（X = CO3(2-)，Cit3-）的形成会导致生理条件下质子弛豫速率显著降低。
