Hachiro Y, Morishita K, Ito T, Sakata J, Baba T, Tsukamoto M, Abe T
Department of Thoracic and Cardiovascular Surgery, Sapporo Medical University, School of Medicine, Japan.
Artif Organs. 1997 Jul;21(7):710-3. doi: 10.1111/j.1525-1594.1997.tb03728.x.
Currently, the clinical application of extracorporeal and assisted circulation using centrifugal pumps is becoming popular. However, a problem in the use of centrifugal pumps is the difficulty in controlling the flow rate when it is a low range. Although we have been controlling the flow rate with a control unit that simply squeezes the blood outlet tube from the outside, hemolysis resulting from turbulent flow in the tube was discovered. Therefore, this control procedure was evaluated experimentally. Two groups were tested as follows: in Group A (n = 10), the tube was squeezed from the outside using the control unit, and in Group B (n = 10), no control unit was used. Blood in each circuit was circulated at 1,500 rpm, and the flow rate was controlled to 250 ml/min using the control unit for Group A. Time-course changes of lactate dehydrogenase (LDH) and free hemoglobin in the blood were measured during 8 h of circulation. There were no significant differences between the 2 groups in the mean values of LDH and free hemoglobin. Therefore, the present low flow rate control provided by the control unit makes it appear to be a simple and useful apparatus for controlling blood circulation using centrifugal pumps.
目前，使用离心泵的体外循环和辅助循环在临床应用中越来越普遍。然而，离心泵使用中的一个问题是在低流量范围内难以控制流速。尽管我们一直使用一个从外部挤压血液出口管的控制单元来控制流速，但发现管内湍流会导致溶血。因此，对该控制程序进行了实验评估。测试了两组如下：A组（n = 10），使用控制单元从外部挤压管子；B组（n = 10），不使用控制单元。每个回路中的血液以1500转/分钟的速度循环，使用A组的控制单元将流速控制在250毫升/分钟。在循环8小时期间测量血液中乳酸脱氢酶（LDH）和游离血红蛋白的时间进程变化。两组之间LDH和游离血红蛋白的平均值没有显著差异。因此，控制单元提供的当前低流速控制似乎是一种使用离心泵控制血液循环的简单且有用的装置。
