Montiès J R, Dion I, Havlik P, Rouais F, Trinkl J, Baquey C
Laboratory for Surgical Research, Faculty of Medicine, Marseilles University, France.
Artif Organs. 1997 Jul;21(7):730-4. doi: 10.1111/j.1525-1594.1997.tb03731.x.
Our group is developing a left ventricular assist device based on the principle of the Maillard-Wankel rotative compressor: it is a rotary, not centrifugal, pump that produces a pulsatile flow. Stringent requirements have been defined for construction materials. They must be light, yet sufficiently hard and rigid, and able to be machined with high precision. The friction coefficient must be low and the wear resistance high. The materials must be chemically inert and not deformable. Also, the materials must be biocompatible, and the blood contacting surface must be hemocompatible. We assessed the materials in terms of physiochemistry, mechanics, and tribology to select the best for hemocompatibility (determined by studies of protein adsorption; platelet, leukocyte, and red cell retention; and hemolysis, among other measurements) and biocompatibility (determined by measurement of complement activation and toxicity, among other criteria). Of the materials tested, for short- and middle-term assistance, we chose titanium alloy (Ti6Al4V) and alumina ceramic (Al2O3) and for long-term and permanent use, composite materials (TiN coating on graphite). We saw that the polishing process of the substrate must be improved. For the future, the best coating material would be diamond-like carbon (DLC) or crystalline diamond coating.
我们的团队正在基于迈拉德 - 汪克尔旋转压缩机原理研发一种左心室辅助装置：它是一种旋转式而非离心式的泵，可产生脉动血流。对建筑材料有严格要求。它们必须轻便，但足够坚硬且刚性好，并且能够高精度加工。摩擦系数必须低，耐磨性要高。材料必须具有化学惰性且不可变形。此外，材料必须具有生物相容性，与血液接触的表面必须具有血液相容性。我们从物理化学、力学和摩擦学方面评估了这些材料，以选择最适合血液相容性（通过蛋白质吸附、血小板、白细胞和红细胞滞留以及溶血等研究确定）和生物相容性（通过补体激活和毒性等测量确定）的材料。在测试的材料中，对于短期和中期辅助，我们选择了钛合金（Ti6Al4V）和氧化铝陶瓷（Al2O3），对于长期和永久使用，选择了复合材料（石墨上的TiN涂层）。我们发现必须改进基材的抛光工艺。未来，最佳的涂层材料将是类金刚石碳（DLC）或晶体金刚石涂层。
