Cooper L V, Stephen G W, Aggett P J
Arch Dis Child. 1977 Aug;52(8):638-41. doi: 10.1136/adc.52.8.638.
Pethidine or an epidural injection of bupivacaine are common forms of obstetric analgesia in Britain. Bupivacaine has been thought to have little effect on the fetus, but neurobehavioural studies have cast doubt on this. We therefore investigated the elimination of these drugs by babies in similar population groups. Bupivacaine was largely eliminated in just over one day, while pethidine required between 2 and 6 days. This could account for the persisting depression in babies whose mothers had received pethidine.
在英国，哌替啶或硬膜外注射布比卡因是常见的产科镇痛方式。布比卡因一直被认为对胎儿影响很小，但神经行为学研究对此提出了质疑。因此，我们调查了相似人群组中婴儿对这些药物的清除情况。布比卡因在一天多一点的时间里基本被清除，而哌替啶则需要2至6天。这可以解释母亲使用过哌替啶的婴儿持续出现的抑制现象。
