新生儿体内哌替啶和布比卡因的消除
Elimination of pethidine and bupivacaine in the newborn.
作者信息
Cooper L V, Stephen G W, Aggett P J
出版信息
Arch Dis Child. 1977 Aug;52(8):638-41. doi: 10.1136/adc.52.8.638.
Abstract
Pethidine or an epidural injection of bupivacaine are common forms of obstetric analgesia in Britain. Bupivacaine has been thought to have little effect on the fetus, but neurobehavioural studies have cast doubt on this. We therefore investigated the elimination of these drugs by babies in similar population groups. Bupivacaine was largely eliminated in just over one day, while pethidine required between 2 and 6 days. This could account for the persisting depression in babies whose mothers had received pethidine.
摘要
在英国，哌替啶或硬膜外注射布比卡因是常见的产科镇痛方式。布比卡因一直被认为对胎儿影响很小，但神经行为学研究对此提出了质疑。因此，我们调查了相似人群组中婴儿对这些药物的清除情况。布比卡因在一天多一点的时间里基本被清除，而哌替啶则需要2至6天。这可以解释母亲使用过哌替啶的婴儿持续出现的抑制现象。
相似文献
1
Elimination of pethidine and bupivacaine in the newborn.新生儿体内哌替啶和布比卡因的消除
Arch Dis Child. 1977 Aug;52(8):638-41. doi: 10.1136/adc.52.8.638.
2
The effects of maternally administered pethidine or epidural bupivacaine on the fetus and newborn.母亲使用哌替啶或硬膜外布比卡因对胎儿及新生儿的影响。
Br J Obstet Gynaecol. 1979 Aug;86(8):598-606. doi: 10.1111/j.1471-0528.1979.tb10820.x.
3
Neonatal respiration, feeding and neurobehavioural state. Effects of intrapartum bupivacaine, pethidine and pethidine reversed by naloxone.
Anaesthesia. 1979 Nov-Dec;34(10):996-1004. doi: 10.1111/j.1365-2044.1979.tb06247.x.
4
Neurobehavioural responses of the newborn. The effect of different forms of maternal analgesia.
Anaesthesia. 1977 Jun;32(6):539-43. doi: 10.1111/j.1365-2044.1977.tb10001.x.
5
Placental transfer of pethidine and bupivacaine.
Neuropharmacology. 1981 Dec;20(12B):1253-8.
6
The addition of pethidine to epidural bupivacaine in labour--effect of changing bupivacaine strength.
Anaesth Intensive Care. 1992 May;20(2):151-5. doi: 10.1177/0310057X9202000205.
7
Comparison of epidural and intramuscular pethidine for analgesia in labour.分娩时硬膜外注射与肌肉注射哌替啶镇痛效果的比较。
Br J Obstet Gynaecol. 1981 Jul;88(7):711-7. doi: 10.1111/j.1471-0528.1981.tb01270.x.
8
The influence of epidural blockade and pethidine administered during delivery on neonatal myocardial performance.分娩期间硬膜外阻滞和哌替啶给药对新生儿心肌功能的影响。
Acta Obstet Gynecol Scand. 1991;70(4-5):315-9. doi: 10.3109/00016349109007879.
9
Subarachnoid bupivacaine and pethidine for caesarean section: assessment of quality of perioperative analgesia and side effects.蛛网膜下腔注射布比卡因和哌替啶用于剖宫产：围手术期镇痛质量及副作用评估
Niger Postgrad Med J. 2011 Sep;18(3):200-4.
10
A comparative study of techniques of postoperative analgesia following caesarean section and lower abdominal surgery.剖宫产与下腹部手术后镇痛技术的比较研究
Anaesth Intensive Care. 1985 May;13(2):123-30. doi: 10.1177/0310057X8501300202.
引用本文的文献
1
The Analysis of Pethidine Pharmacokinetics in Newborn Saliva, Plasma, and Brain Extracellular Fluid After Prenatal Intrauterine Exposure from Pregnant Mothers Receiving Intramuscular Dose Using PBPK Modeling.使用生理药代动力学（PBPK）模型分析产前宫内暴露于接受肌肉注射剂量的母亲的新生儿唾液、血浆和脑细胞外液中的哌替啶药代动力学。
Eur J Drug Metab Pharmacokinet. 2023 May;48(3):281-300. doi: 10.1007/s13318-023-00823-x. Epub 2023 Apr 5.
2
[Systemic analgesia during labour.].
Schmerz. 1994 Mar;8(1):5-11. doi: 10.1007/BF02527504.
3
Clinical pharmacokinetics and pharmacodynamics of opioid analgesics in infants and children.阿片类镇痛药在婴幼儿及儿童中的临床药代动力学与药效学
Clin Pharmacokinet. 1995 May;28(5):385-404. doi: 10.2165/00003088-199528050-00004.
4
Placental transfer of pethidine and norpethidine and their pharmacokinetics in the newborn.哌替啶和去甲哌替啶的胎盘转运及其在新生儿中的药代动力学
Eur J Clin Pharmacol. 1980 Jul;18(1):25-30. doi: 10.1007/BF00561475.
5
Naloxone pharmacokinetics in the newborn.新生儿纳洛酮的药代动力学
Br J Clin Pharmacol. 1980 Jun;9(6):609-12. doi: 10.1111/j.1365-2125.1980.tb01088.x.
6
Preliminary studies on the disposition of meptazinol in the neonate.美普他酚在新生儿体内处置的初步研究。
Br J Clin Pharmacol. 1981 Jul;12(1):88-90. doi: 10.1111/j.1365-2125.1981.tb01862.x.
7
Routes of meptazinol conjugation in the neonate.美普他酚在新生儿体内的结合途径。
Br J Clin Pharmacol. 1982 Nov;14(5):748-50. doi: 10.1111/j.1365-2125.1982.tb04970.x.
8
Maternal kinetics and transplacental passage of pethidine during labour.分娩期间哌替啶的母体动力学及经胎盘转运
Br J Clin Pharmacol. 1982 May;13(5):653-9. doi: 10.1111/j.1365-2125.1982.tb01432.x.
9
Obstetric analgesia. Clinical pharmacokinetic considerations.产科镇痛。临床药代动力学考量。
Clin Pharmacokinet. 1986 Jul-Aug;11(4):283-98. doi: 10.2165/00003088-198611040-00002.
10
The disposition of meptazinol after single and multiple intravenous administration to pregnant and non-pregnant women.
Eur J Clin Pharmacol. 1989;36(3):273-7. doi: 10.1007/BF00558159.
本文引用的文献
1
EFFECTS OF MEPERIDINE ON THE NEWBORN INFANT.
Am J Obstet Gynecol. 1964 Aug 15;89:1009-15. doi: 10.1016/0002-9378(64)90292-3.
2
Neurobehavioral responses of newborn infants after maternal epidural anesthesia.
Anesthesiology. 1974 Feb;40(2):121-8. doi: 10.1097/00000542-197402000-00005.
3
Obstetric meperidine usage and assessment of neonatal status.
Anesthesiology. 1974 Feb;40(2):116-20. doi: 10.1097/00000542-197402000-00004.
4
The determination of bupivacaine, lignocaine and mepivacaine in human blood.人血中布比卡因、利多卡因和甲哌卡因的测定。
J Pharm Pharmacol. 1968 Sep;20(9):704-8. doi: 10.1111/j.2042-7158.1968.tb09841.x.
5
Blood concentrations of pethidine and pentazocine in mother and infant at time of birth.
J Pharm Pharmacol. 1967 Dec;19:Suppl:50S-52S.
6
Lumbar epidural analgesia with bupivacaine in labor. Drug concentration in maternal and neonatal blood at birth and during the first day of life.分娩时布比卡因用于腰椎硬膜外镇痛。出生时及出生后第一天母婴血液中的药物浓度。
Am J Obstet Gynecol. 1975 Dec 15;123(8):839-44. doi: 10.1016/0002-9378(75)90859-5.
7
Toxicity of local anesthetics in the fetus and the newborn.局部麻醉药对胎儿及新生儿的毒性
Bull N Y Acad Med. 1976 Feb;52(2):222-5.
8
Anesthesia for cesarean section IV: placental transfer and neonatal elimination of bupivacaine following epidural analgesia for elective cesarean section.
Acta Anaesthesiol Scand. 1976;20(2):141-6. doi: 10.1111/j.1399-6576.1976.tb05020.x.
9
Lumbar epidural analgesia with bupivacaine in labor. Determination of drug concentration and pH in fetal scalp blood, and continuous fetal heart rate monitoring.
Am J Obstet Gynecol. 1975 Feb 1;121(3):360-5.
10
The role of analgesics in respiratory depression: a rabbit model.镇痛药在呼吸抑制中的作用：兔模型
Anaesthesia. 1977 Apr;32(4):324-7. doi: 10.1111/j.1365-2044.1977.tb11629.x.
Zotero 插件