椭圆叶米仔兰的细胞毒性和抗血小板聚集成分
Cytotoxic and antiplatelet aggregation principles from Aglaia elliptifolia.
作者信息
Wu T S, Liou M J, Kuoh C S, Teng C M, Nagao T, Lee K H
机构信息
Department of Chemistry, National Cheng-Kung University, Tainan, Taiwan, Republic of China.
出版信息
J Nat Prod. 1997 Jun;60(6):606-8. doi: 10.1021/np970163+.
PMID:9214732
Abstract
Two related 1H-2,3,3a,8b-tetrahydrocyclopenta[b]benzofurans, aglafolin (1a) and rocaglamide (2), isolated from the stems of Aglaia elliptifolia, showed significant cytotoxicity in six cancer cell lines. Aglafolin (1a) was also found to completely block platelet aggregation caused by arachidonic acid and platelet-activating factor at 100 microM and 2 ng/mL, respectively.
摘要
从椭圆叶米仔兰茎中分离得到的两种相关的1H-2,3,3a,8b-四氢环戊并[b]苯并呋喃，即aglafolin（1a）和rocaglamide（2），在六种癌细胞系中显示出显著的细胞毒性。还发现aglafolin（1a）分别在100 microM和2 ng/mL时能完全阻断由花生四烯酸和血小板活化因子引起的血小板聚集。
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